Mig1 recruits a “repressing complex” containing the Tup1 protein. This complex is recruited by many yeast DNA-binding proteins that repress transcription, including the alpha2 protein involved in controlling the mating-type specific. Tup1 also has counterparts in mammalian cells, choose correct mechanisms have been proposed to explain the repressing effect of Tup1.

I-Tup1 acts on nucleosomes either through recruiting histone deacetylases and/or by positioning a nucleosome at or near the transcription start site.

II-Tup1 interacts directly with the transcriptional machinery at the promoter and inhibits initiation.

#Question id: 849

#Unit 1. Molecules and their Interaction Relevant to Biology

The rigidity of the peptide unit and the restricted set of allowed phi and psi angles limits the number of structures accessible to the unfolded form sufficiently to allow:-

#Question id: 850

#Unit 1. Molecules and their Interaction Relevant to Biology

The experimental inverse of protein structure prediction, has provided insights into protein folding and stability. Protein design attempts to construct an amino acid sequence that will form a structure such as a sandwich of β sheets or a bundle of α helices;

#Question id: 851

#Unit 1. Molecules and their Interaction Relevant to Biology

Methods is the Rosetta program, formulated by David Baker. To satisfy the program’s computational needs, a volunteer network of ∼100,000 computers, known as Rosetta@home, provides the 500,000 or so hours of processing time required to generate a structure;

#Question id: 852

#Unit 1. Molecules and their Interaction Relevant to Biology

.________ enzyme revealed the relation between the amino acid sequence of a protein and its conformation.

#Question id: 853

#Unit 1. Molecules and their Interaction Relevant to Biology

In the presence of a large excess of _______ the disulfides (cystines) are fully converted into sulfhydryls (cysteines).

#Question id: 854

#Unit 1. Molecules and their Interaction Relevant to Biology

Many conditions including type 2 diabetes, Alzheimer  disease, Huntington disease and parkinson disease are associated with the misfolding mechanism a soluble protein that is normally secreted from the cell is secreted in the missfold state and converted into an insoluble extracellular fibre the diseases are correctly referred to as