#Question id: 12742
#Unit 13. Methods in Biology
#Question id: 15990
#Unit 12. Applied Biology
#Question id: 12378
#Unit 10. Ecological Principles
#Question id: 4456
#Unit 3. Fundamental Processes
Correct statement about two striking structural changes are seen in the enzyme upon isomerization from the closed to the open complex;
A. First, the pincers at the front of the enzyme clamp down tightly on the downstream DNA.
B. Second, there is a major shift in the position of the amino-terminal region of s. When not bound to DNA, s region 3.2 lies within the active center cleft of the holoenzyme, blocking the path that, in the open complex, is followed by the template DNA strand.
C. In the open complex, region 1.1 shifts some 50 A˚ and is now found on the outside of the enzyme, allowing the DNA access to the cleft.
D. Region 1.1 of s is highly negatively charged ( just like DNA).
#Question id: 2690
#Unit 2. Cellular Organization
What do you think is the requirement of Intergenic DNA in higher organisms?