Malonate is an analog of succinate not normally present in cells, is a strong competitive inhibitor of succinate dehydrogenase, and its addition to mitochondria blocks the activity of the

TLS Online TPP Program

#Question id: 30100

#Unit 1. Structure and Function of Biomolecules

In the catabolism of CTP: <

TLS Online TPP Program

#Question id: 30101

#Unit 1. Structure and Function of Biomolecules

The formation of dATP for DNA synthesis occurs primarily by:

TLS Online TPP Program

#Question id: 30102

#Unit 1. Structure and Function of Biomolecules

Which of the following would NOT be expected to contribute to hyperuricemia (gout)?

TLS Online TPP Program

#Question id: 30103

#Unit 1. Structure and Function of Biomolecules

Direct sources of purine ring atoms in the de novo synthesis of IMP include:

1. glutamine.

2. a component of the tetrahydrofolate one-carbon pool.

3. aspartate.

4. glycine.

TLS Online TPP Program

#Question id: 30104

#Unit 1. Structure and Function of Biomolecules

A nucleoside phosphorylase:

1. cleaves a nucleoside with the production of ribose 1-phosphate.

2. is necessary for the major salvage pathway for pyrimidines.

3. is used in the degradation of purine nucleotides.

4. is responsible for the equilibration of nucleoside monophosphates and nucleoside diphosphate.

TLS Online TPP Program

#Question id: 30105

#Unit 1. Structure and Function of Biomolecules

Methotrexate is an inhibitor of dihydrofolate reductase. Administration of methotrexate would inhibit:

1. de novo synthesis of UMP.

2. conversion of dUMP to dTMP.

3. conversion of IMP to GMP.

4. de novo synthesis of IMP