#Question id: 7456
#General Aptitude
#Question id: 15306
#Unit 4. Cell Communication and Cell Signaling
The transformation of a normal cell to a cancer cell is accompanied by the loss of function of one or more tumor‐suppressor genes. High‐throughput sequencing studies have identified hundreds of genes that are implicated as tumor suppressors in humans. Some of the better characterized genes;
|
Gene |
Primary tumor |
Proposed function |
|
i) APC |
Colorectal |
Binds β
‐catenin acting as transcription factor |
|
ii) BRCA1 |
Breast |
DNA repair |
|
iii) MSH2, MLH1 |
Melanoma, pancreatic |
p16: Cdk inhibitor ARF: stabilizes p53 |
|
iv) E‐Cadherin |
Breast, colon |
Cell adhesion molecule |
|
v) INK4a |
Colorectal |
Mismatch repair |
|
vi) NF1 |
Neurofibromas |
Activates GTPase of Ras |
Choose incorrect matching regarding tumor‐suppressor genes/primary tumor/proposed functions; |
#Question id: 2887
#Unit 2. Cellular Organization
Which of the following reasons has led to the evolutionary selection of an extra methyl group in DNA?
#Question id: 5228
#Unit 11. Evolution and Behavior
Multigene families are
#Question id: 10696
#Unit 10. Ecological Principles
In a new area two species A and B was discovered and taking energy from another species X and Y respectively. Following some is life history trait of species.
I- A species is often larger than X
II- Each A species taking energy from many X
III- One Y usually supports populations of B species
IV- Fatality of Y is Mild to severe
Which of the following is correct observation of above species?