TLS Online TPP Program

#Question id: 5654


Two human disorders, Prader-Willi syndrome and Angelman syndrome, occur when a small deletion in a specific region of chromosome 15 is contributed by either the father or mother, respectively. Why does this small deletion not behave as a recessive allele for either syndrome, that is, why is its loss not made up for by the good copy of the region on chromosome 15 contributed by the other parent?

#Unit 5. Developmental Biology
  1. This portion of chromosome 15 is invariably mutated, so the other parent contributes recessive alleles that are thus homozygous and perturb development.

  2. The copy of chromosome 15 from the other parent has genes in the region of the deletion that are imprinted, and thus inactive; in the absence of any active copies of these genes, development cannot proceed normally.

  3. The genes in this portion of chromosome 15 are special in that they are required in two copies for normal development, and so the loss of one set does not allow normal development.

  4. Chromosomes with deletions do not go through mitosis correctly, so cell divisions in the embryo result in cells with abnormal numbers of chromosomes, and these cells do not contribute properly to the development of the organism.

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TLS Online TPP Program

#Question id: 14707

#Unit 5. Developmental Biology

Which of the following organ belongs to the internal layer of gastrula?

TLS Online TPP Program

#Question id: 14708

#Unit 5. Developmental Biology

Difference between gastrulation in Xenopus and sea urchin;
I. In Xenopus, formation of blastopore: mesoderm and endoderm move inside by involution over blastopore lip.
II. In sea urchin, formation of blastopore: mesodermal cells migrate into the interior; endoderm moves inside by invagination of the epithelial sheet.

TLS Online TPP Program

#Question id: 14709

#Unit 5. Developmental Biology

Choose right statement about cleavage pattern and gastrulation movements;
1.At the end of cleavage the animal embryo is essentially a closed sheet of cells, which is often in the form of a sphere enclosing a fluid-filled interior. Gastrulation, strictly the formation of the gut, converts this sheet into a solid three-dimensional embryonic animal body. 
2.During cleavage, cells move into the interior of the embryo, and the regions of endoderm. and mesoderm. which were originally adjacent in the cell sheet, take up their appropriate positions in the embryo.
3. Gastrulation results from a well- defined spatio-temporal pattern of change in cell shape, cell movement, and change in cell adhesiveness, the main forces of which are generated by localized contractions.

TLS Online TPP Program

#Question id: 14710

#Unit 5. Developmental Biology

Splitting of one cellular sheet into two more or less parallel sheets. While on a cellular basis it resembles ingression, the result is the formation of a new (additional) epithelial sheet of cells, choose right gastrulation movement;

TLS Online TPP Program

#Question id: 14711

#Unit 5. Developmental Biology

Choose right explanations of gastrulation movements,  


TLS Online TPP Program

#Question id: 14712

#Unit 5. Developmental Biology

 Match the following cleavage pattern, with their egg type and cleavage type

CLEAVAGE PATTERNEGG TYPECLEAVAGE TYPE
1. HOLOBLASTIC CLEAVAGEa. IsolecithalI. Spiral cleavage
b. MesolecithalII. Displaced radial cleavage
2. MEROBLASTIC CLEAVAGEc. TelolecithalIII. Discoidal cleavage
d. CentrolecithalIV. Superficial cleavage