TLS Online TPP Program

#Question id: 5654


Two human disorders, Prader-Willi syndrome and Angelman syndrome, occur when a small deletion in a specific region of chromosome 15 is contributed by either the father or mother, respectively. Why does this small deletion not behave as a recessive allele for either syndrome, that is, why is its loss not made up for by the good copy of the region on chromosome 15 contributed by the other parent?

#Unit 5. Developmental Biology
  1. This portion of chromosome 15 is invariably mutated, so the other parent contributes recessive alleles that are thus homozygous and perturb development.

  2. The copy of chromosome 15 from the other parent has genes in the region of the deletion that are imprinted, and thus inactive; in the absence of any active copies of these genes, development cannot proceed normally.

  3. The genes in this portion of chromosome 15 are special in that they are required in two copies for normal development, and so the loss of one set does not allow normal development.

  4. Chromosomes with deletions do not go through mitosis correctly, so cell divisions in the embryo result in cells with abnormal numbers of chromosomes, and these cells do not contribute properly to the development of the organism.

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TLS Online TPP Program

#Question id: 11059

#Unit 7. System Physiology – Animal

A healthy, 45-year-old man is reading the newspaper. Which of the following muscles are used for quiet breathing?

TLS Online TPP Program

#Question id: 11060

#Unit 7. System Physiology – Animal

A healthy, 25-year-old medical student participates in a 10-km charity run for the American Heart Association. Which of the following muscles does the student use (contract) during expiration?

TLS Online TPP Program

#Question id: 11061

#Unit 7. System Physiology – Animal

The pleural pressure of a normal 56-year-old woman is approximately −5 cm H2O during resting conditions immediately before inspiration (i.e., at functional residual capacity). What is the pleural pressure (in cm H2O) during inspiration?

TLS Online TPP Program

#Question id: 11062

#Unit 7. System Physiology – Animal

The alveolar pressure of a normal 77-year-old woman is approximately 1 cm H2O during expiration. What is the alveolar pressure during inspiration (in cm H2O)?

TLS Online TPP Program

#Question id: 11063

#Unit 7. System Physiology – Animal

A man inspires 1000 ml from a spirometer. The intrapleural pressure was −4 cm H2O before inspiration and −12 cm H2O the end of inspiration. What is the compliance of the lungs?

TLS Online TPP Program

#Question id: 11064

#Unit 7. System Physiology – Animal

The diagram above shows three different compliance curves (S, T, and U) for isolated lungs subjected to various transpulmonary pressures. Which of the following best describe the relative compliances for the three curves?