TLS Online TPP Program

#Question id: 5660


Following statement regarding to acrosome reaction in sea urchin.

A. Activation of the acrosome reaction serves as a barrier to intraspecies fertilizations.

B. The acrosome reaction is initiated by sulfate-containing polysaccharides in the egg jelly that bind to specific receptors located directly above the acrosomal vesicle on the sperm cell membrane.

C. These polysaccharides are often highly species specific, but egg jelly factors from one species of sea urchin generally activate the acrosome reaction in closely related species.

D. The elevated Ca2+ level in a relatively basic cytoplasm triggers the fusion of the acrosomal membrane with the adjacent sperm cell membrane, releasing enzymes that can lyse a path through the egg jelly to the vitelline envelope.

Which of the following statements are correct?

#Unit 5. Developmental Biology
  1. A and B

  2. A and C

  3. B and D

  4. B only

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TLS Online TPP Program

#Question id: 795

#Unit 1. Molecules and their Interaction Relevant to Biology

A single-stranded DNA molecule contains 40 nucleotides and has the sequence 5’-(GA)20-3’. When this single strand binds to a complementary DNA strand,

TLS Online TPP Program

#Question id: 796

#Unit 1. Molecules and their Interaction Relevant to Biology

Which statement best describes the distinction between the purposes of the two RNAi pathways within the eukaryotic cell?

TLS Online TPP Program

#Question id: 797

#Unit 1. Molecules and their Interaction Relevant to Biology

With respect to microRNAs, which, if any, of the following statements, is FALSE?)

A. MicroRNA genes often occur in gene clusters within introns of protein-coding genes and are usually transcribed by RNA polymerase II.

B. Like an mRNA a miRNA is initially produced as a larger precursor RNA that, like the great majority of mRNAs, usually has a 5’ cap and a poly(A) tail.

C. MicroRNAs are produced by germ-line cells only.

D. A miRNA is initially produced as a duplex RNA but in order to work it needs to be converted into a single-strand RNA.

E. MicroRNAs usually work as transcription factors.

TLS Online TPP Program

#Question id: 798

#Unit 1. Molecules and their Interaction Relevant to Biology

Match the structural properties of DNA with the respective types of DNA in which they are found.

COLUMN – ICOLUMN – II
A. Pitch per turn of helix

1. 45.6 angstrom


2. 24.6 angstrom


3. 33.2 angstrom

B. Helix packing diameter

1. 23.7 angstrom


2. 18.4 angstrom


3. 25.5 angstrom

C. Major-groove proportions

1. Flattened out on helix surface


2. Extremely narrow but very deep


3. Wide and of intermediate depth

D. Minor-groove proportions

1. Very broad but shallow


2. Extremely narrow but very deep


3. Narrow and of intermediate depth

TLS Online TPP Program

#Question id: 799

#Unit 1. Molecules and their Interaction Relevant to Biology

The two cleavage reactions required to generate the miRNA from these primary transcripts are mediated by two distinct RNases. A characteristic of both these enzymes is that they recognize and cleave RNAs on the basis of the structure of their substrates rather than their specific sequence. Which of the following statement is INCORRECT regarding the cleavage reactions that produces a mature RNA?

TLS Online TPP Program

#Question id: 800

#Unit 1. Molecules and their Interaction Relevant to Biology

Following table lists the two major forms of DNA duplexes, conformation of base attached to the sugar and the nature of major and minor grooves.

DNA duplex

Properties

(A)  A form

(i) Syn conformation of the base to sugar

(B)  B form

(ii) Anti conformation of the base to sugar

 

(iii) Wide major groove

 

(iv) Narrow major groove

 

(v) Wide minor groove 

 

(vi) Narrow minor groove 

 

(vii) C-3’ endo sugar puckering

 

(viii) C-2’ endo sugar puckering