Given some statements about Hedgehog processing and secretion;

a) autoproteolytic activity that cleaves off the C-terminus to reveal a signal sequence that marks the protein for secretion 

b) autoproteolytic activity that cleaves off the N-terminus to reveal a signal sequence that marks the protein for secretion 

c) Secretion requires the addition of cholesterol and palmitic acid

d) Secretion requires the  modification of Hh by Glycosylation

Which of the following is correct prediction about processing and secretion of Hh?

#Question id: 1134

#Unit 4. Cell Communication and Cell Signaling

Arrange the following proteins in the proper order in which they become activated in the MAPK signaling pathway:

a. MAP kinase                         b. MEK           c. Ras              d. Raf              e. RTK            

#Question id: 1135

#Unit 4. Cell Communication and Cell Signaling

Which of the following is a direct substrate of MAP kinase?

a. TCF             b. SRF             c. SRE             d. p90RSK      e. CREB

#Question id: 1136

#Unit 4. Cell Communication and Cell Signaling

Which of the following signaling pathways can be activated by activation of receptor tyrosine kinases?

a. phospholipase Cγ                b. PI-3 kinase

c. MAP kinase                         d. none of the above

#Question id: 1137

#Unit 4. Cell Communication and Cell Signaling

A loss-of-function mutation in PTEN phosphatase results in

a. increased cell proliferation.            

b. decreased cell proliferation.

c. increased apoptosis.                                   

d. decreased apoptosis.

#Question id: 1138

#Unit 4. Cell Communication and Cell Signaling

A loss-of-function mutation in Wnt would have a phenotype similar to a

a. gain-of-function mutation in GSK-3.                    

b. gain-of-function mutation in β-catenin.

c. loss-of-function mutation in GSK-3.                     

d. loss-of-function mutation in β-catenin.

#Question id: 1139

#Unit 4. Cell Communication and Cell Signaling

In paracrine signaling, the signaling molecule: