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#Question id: 5662


Mouse sperm contain receptor proteins that bind to a glycoprotein (ZP3) in the zona pellucida of mouse eggs. Binding of ZP3 receptors to ZP3 initiates the sperm’s acrosomal reaction. All of the following experimental observations would be expected EXCEPT:

#Unit 5. Developmental Biology
  1. Injecting eggs with antibodies that bind to ZP3 blocks in vitro fertilization.

  2. Incubating sperm with purified ZP3 prior to mixing sperm and eggs blocks in vitro fertilization.

  3. Coating synthetic beads with a different glycoprotein, ZP2, fails to lead to sperm aggregation on the beads.

  4. Coating synthetic beads with ZP3 leads to sperm aggregation on the beads.

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