A recessive allele (a) that causes a genetic disease has a frequency (q) of 0.04. If the population mates randomly (F = 0.36), then how much proportion of lethality is increase due to inbreeding?

TLS Online TPP Program

#Question id: 2830

#Unit 2. Cellular Organization

The NtrC protein from E. coli

a. is a σ54 RNA polymerase.             

b. stimulates transcription of the glnA gene.

c. is activated by a protein kinase called NtrB.

d. binds both to an enhancer site upstream of the glnA gene and to RNA polymerase.

e. has ATPase activity.

TLS Online TPP Program

#Question id: 2831

#Unit 2. Cellular Organization

Specific DNA control elements in promoters can

a. interact with general transcription factors.

b. interact with repressor proteins.                 

c. interact with activator proteins.

d. remain unavailable because of condensed chromatin. 

TLS Online TPP Program

#Question id: 2832

#Unit 2. Cellular Organization

Reporter genes are used to

a. express enzymes that are not easily assayed in cell extracts.

b. express enzymes that are easily assayed in cell extracts.

c. characterize DNA control elements.                     

d. characterize reporter plasmids.

TLS Online TPP Program

#Question id: 2835

#Unit 2. Cellular Organization

An enhancer

a. can be located upstream of a promoter.

b. can be located downstream of a promoter.

c. can be located a variable distance from the promoter.

d. is always located within 1 kb of the promoter.

e. can be cell-type-specific.

TLS Online TPP Program

#Question id: 2836

#Unit 2. Cellular Organization

The fact that a specific protein leaves a “footprint” on a DNA molecule is indicative of

a. a lack of interaction between the specific protein and DNA.

b. protection from DNAse by the specific protein.

c. binding of the specific protein to all types of DNA.

d. binding of the specific protein to a specific sequence of DNA.

TLS Online TPP Program

#Question id: 2837

#Unit 2. Cellular Organization

The C-terminal activation domain of transcriptional activators is capable of

a. binding to DNA.                 

b. stimulating transcription.

c. interaction with other transcriptional machinery.

d. functioning in a fusion with a DNA-binding domain from an unrelated transcriptional activator.