TLS Online TPP Program

#Question id: 5670


Embryonic stem cells can be induced in the laboratory to differentiate into muscle, nerve, pancreatic, and other specialized cell types. It has recently become possible to trigger the dedifferentiation of somatic cells back into pluripotent cells (so-called induced pluripotent stem cells or iPS cells) by artificially enhancing the production of a relatively small number of key transcriptional factors known to be required for maintenance of pluripotency. Examples of such transcription factors are OCT4 and NANOG. The production of OCT4 and NANOG (and other key regulatory proteins) is stimulated by a transcription factor known as FOXP1, a member of the Forkhead family of DNA-binding proteins. There are two isoforms of FOXP1.

Which of the following statement regarding to FOXP1 is incorrect?

#Unit 5. Developmental Biology
  1. The protein encoded by the exon 18b–carrying mRNA is called FOXP1-ES: this activates genes (OCT4, NANOG, etc.) that promote dedifferentiation, and thus stimulates iPS cell formation.

  2. In the exon 18a–containing form encodes FOXP1 itself, and this has the opposite effect: it fails to stimulate expression of OCT4 and NANOG and instead actives genes that promote differentiation.

  3. FOXP1 binds to DNA via a domain known as a Winged helix, which recognizes a particular DNA sequence.

  4. The switch from exon 18a to exon 18b substitutes 3 residues in the Winged helix region of the protein including six amino acids that are known to contact DNA.

More Questions
TLS Online TPP Program

#Question id: 10498

#Unit 6. System Physiology – Plant

Which one of the following inhibitor that inhibits blue light–stimulated stomatal opening and the inhibition is concentration dependent, while does not block red light–stimulated opening.

TLS Online TPP Program

#Question id: 10499

#Unit 6. System Physiology – Plant

Stomata from intact, attached leaves of Arabidopsis illuminated with blue, red, and green light in a growth chamber, increases and decreases their aperture in response to light.

 

Find the CORRECT statements from the above graph.

i) Stomatal aperture increases when the green light is turned off, and close when the green light is turned on again

ii) Stomata from the phototropin-less double mutant phot1/phot2 respond to blue light and open further when green light is turned off

iii) stomata from the zeaxanthin less mutant npq1 do not respond to blue light and least effect to opening of the stomata further when green light is turned off

iv) the npq1 mutant and phot1/phot2 double mutant response indicate that the green reversal of the blue-light response requires zeaxanthin but also phototropin

TLS Online TPP Program

#Question id: 10500

#Unit 6. System Physiology – Plant

Orange carotenoid protein (OCP) is involve in the photoprotection, these protein complex function as light intensity sensor provides;

TLS Online TPP Program

#Question id: 10501

#Unit 6. System Physiology – Plant

Which defenses require specific detection systems and signal transduction pathways that can sense the presence of an herbivore or pathogen and alter gene expression and metabolism accordingly

TLS Online TPP Program

#Question id: 10502

#Unit 6. System Physiology – Plant

Arabidopsis roots in iron-deficient growth media, thereby facilitating increased iron uptake. The resulting increase in iron content of the plants by

TLS Online TPP Program

#Question id: 10503

#Unit 6. System Physiology – Plant

A Pseudomonas species that synthesizes the antifungal compound against the pathogenic fungus Gaeumannomyces graminis known as