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TLS Online TPP Program

#Question id: 5807

Which of the following would be an example of a germline mutation?

#Unit 8. Inheritance Biology

  1. Exposure to excessive UV radiation causes changes in the DNA of a skin cell, leading to basal cell carcinoma (skin cancer).

  2. In a very early human embryo, a mistake in mitosis causes loss of a Y chromosome in one daughter cell. The resulting child is a fertile male who is chromosomally partially male (XY) and partially female with Turner's syndrome (XO).

  3. A man with normal chromosomes has a hip X-ray without a protective shield. Ten months later, his wife gives birth to a child with a chromosomal deletion.

  4. An embryo missing one copy of the third chromosome is miscarried very early in pregnancy.

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TLS Online TPP Program

#Question id: 12994

#Unit 1. Structure and Function of Biomolecules

α-helix changes their configurations according to the environment then
a. when found in aqueous or plasm environment 
b. when found in membrane or hydrophobic environment
in the given condition interaction will be 
TLS Online TPP Program

#Question id: 12995

#Unit 1. Structure and Function of Biomolecules

Which of the following constraints affect the stability α-helix, 
a) the intrinsic propensity of an amino acid residue to form an α-helix.
b) the interactions between R groups.
c) the bulkiness of adjacent R groups.
d) the occurrence of Pro and Gly residues.
TLS Online TPP Program

#Question id: 12996

#Unit 1. Structure and Function of Biomolecules

Which of the following is incorrect regarding to α-helix
a) In the α helix, the first four NH groups and last four CO groups will normally lack backbone  hydrogen bonds.
b) the length of an amino acid in α-helix reduced almost 3 times than linear structure.
c) the frequent occurrence of Pro and Gly residues favour α-helix formation.
d) dihedral (ϕ and ψ) angle should be close to -57 and -47.
TLS Online TPP Program

#Question id: 12997

#Unit 1. Structure and Function of Biomolecules

Which of the given reason is correct to minimize the repulsion in an α-helix
a) positively charged amino acids are often found near the amino terminus of the helical segment
b) negatively charged amino acids are often found near the amino terminus of the helical segment
c) positively charged amino acids are often found near the C-terminus of the helical segment.
d) negatively charged amino acids are often found near the C-terminus of the helical segment.
TLS Online TPP Program

#Question id: 12998

#Unit 1. Structure and Function of Biomolecules

Match with appropriate bonding pattern

Helix typeHydrogen bonding
a. α-helix1. n, n+3
b. 310 helix2. n, n+5
c. π helix3. n, n+4
TLS Online TPP Program

#Question id: 12999

#Unit 1. Structure and Function of Biomolecules

Proline and glycine both disturb the symmetry of α-helix which of the following are true regarding to these two amino acids
a) proline changes the orientation of hetropolymeric α-helix hence proline can be placed only as 1st amino acid residue near to C-terminus 
b) proline changes the orientation of polymeric α-helix hence proline can be placed only as 1st amino acid residue near to N-terminus
c) glycine disrupts the heteropolymeric α-helix by changing the helicity.
d) homopolymer of proline and glycine can form stable helix.