If a cell has an adequate supply of adenine nucleotides but requires more guanine nucleotides for protein synthesis:

1. Glutamine-PRPP amidotransferase will not be fully inhibited.

2. AMP will be a feedback inhibitor of the condensation of IMP with aspartate.

3. ATP will stimulate the production of GMP from IMP.

4. ATP will inhibit nucleoside diphosphate reductase.

TLS Online TPP Program

#Question id: 12210

#Unit 7. System Physiology – Animal

Which of the following stimulates the secretion of parathyroid hormone (PTH)?

TLS Online TPP Program

#Question id: 12211

#Unit 7. System Physiology – Animal

A 57-year-old man is admitted as an emergency for upper GI bleeding. Endoscopy reveals multiple ulcers in the duodenum. Serum gastrin levels are eight-fold higher compared to normal. Zollinger-Ellison syndrome (ZES, gastrinoma) is suspected. Administration of which of the following substances is useful in confirming the diagnosis?

TLS Online TPP Program

#Question id: 12212

#Unit 7. System Physiology – Animal

 A 71-year-old man with upper abdominal pain and blood in the stool takes NSAIDS for the pain and washes it down with whiskey. Pentagastrin administration produced lower than predicted levels of gastric acid secretion. Secretion of which of the following substances is most likely to be diminished in this patient with gastritis?

TLS Online TPP Program

#Question id: 12213

#Unit 7. System Physiology – Animal

The gastric phase of gastric secretion accounts for about 60% of the acid response to a meal. Which of the following can virtually eliminate the secretion of acid during the gastric phase?

TLS Online TPP Program

#Question id: 12214

#Unit 7. System Physiology – Animal

A 53-year-old man with a recurrent history of ulcer disease associated with diarrhea and a strong family history of duodenal ulcer disease is suspected of having Zollinger-Ellison syndrome (gastrinoma). Secretin (2 units/kg) was given as a rapid intravenous injection to test for gastrinoma. Which of the following results would support the existence of gastrinoma following secretin administration?

TLS Online TPP Program

#Question id: 12215

#Unit 7. System Physiology – Animal

Damage to the gastric mucosal barrier is a forerunner of gastric ulcer. Which of the following can both damage the gastric mucosal barrier and stimulate gastric acid secretion?