TLS Online TPP Program

#Question id: 30112


With respect to the de novo synthesis of nucleotides, which one of the following statements is INCORRECT?

#Unit 1. Molecules and their Interaction Relevant to Biology
  1. Biosynthesis of both purine and pyrimidine nucleotides begin with ribose‐5‐phosphate and purine or pyrimidine rings are built on it.
  2. The first purine nucleotide biosynthesized by de novo pathway is inosinic acid or inosine‐monophosphate.
  3. The first pyrimidine nucleotide biosynthesized by de novo pathway is orotidylic acid or orotidine monophosphate
  4. Thymidylate or TMP is synthesized as deoxy‐TMP from deoxy‐UMP by thymidylate synthetase.
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TLS Online TPP Program

#Question id: 4444

#Unit 3. Fundamental Processes

The homologous omega subunit of bacterial RNA polymerase in eukaryotic polymerases is,

TLS Online TPP Program

#Question id: 4445

#Unit 3. Fundamental Processes

The active site, which is made up of RPB1 and RPB2, from both these subunits, is found at the base of the pincers within a region called the “active center cleft” . The active site works according to the two-metal ion catalytic mechanism for nucleotide addition proposed for all types of polymerase;

TLS Online TPP Program

#Question id: 4446

#Unit 3. Fundamental Processes

Transcription start site is designated with the;

TLS Online TPP Program

#Question id: 4447

#Unit 3. Fundamental Processes

Sequences in the direction in which transcription proceeds are referred to as __?from the start site, and allotted a? value.

TLS Online TPP Program

#Question id: 4448

#Unit 3. Fundamental Processes

Three defined steps in a transcription cycle; choose correct one

1a. Closed complex

In this form, the DNA remains double-stranded, and the enzyme is bound to one face of the helix. I

1b. Open complex

In which the DNA strands separate over a distance of 13 bp around the start site to form the transcription bubble. In the next stage of initiation,

2. Promoter escape

Incorporation of the first 10 or so ribonucleotides is a rather inefficient process, and at that stage, the enzyme often releases short transcripts and then begins synthesis again

3. Initial transcribing complex.

Once an enzyme makes a transcript longer than 10 nucleotides, it is said to have

TLS Online TPP Program

#Question id: 4449

#Unit 3. Fundamental Processes

Promoters recognized by polymerase containing s70 share the following characteristic structure;