TLS Online TPP Program

#Question id: 31092


GPCR pathway mainly via a G protein called Gq, activates PLC-b. Mentioned below are some of the steps. Which of the following not correct?

#Unit 4. Cell Communication and Cell Signaling
  1. PLC-b acts on phosphatidyl inositol 4,5-biphosphate (PIP2), which is present in the inner half of the plasma membrane lipid bilayer.
  2. Activated PLC-p cleaves the PIP2 to generate two products: inositol 1,4,5- triphosphate (IP3) and diacylglycerol (DAG).
  3. IP3 is a small lipid-soluble molecule that binds to IP3 receptor on plasma membrane thereby increasing Ca2+ concentration in the cytosol.
  4. DAG gets further cleaved to release arachidonic acid, which is used in the synthesis of eicosanoids including prostaglandins. DAG also activates ca2+ dependent PKC.