Wnt signaling receptor, Frizzled (Fz), shows similarity with: 

#Question id: 2976

#Unit 2. Cellular Organization

Match the following Regulators with its functions.

Which of the following is correct?

#Question id: 2977

#Unit 2. Cellular Organization

The mitotic exit network that localizes to spindle pole bodies and whose activity is regulated by spindle position belongs to the family of signaling pathways known as the Hippo pathway in metazoans. Following statements are-

A. The conserved core of the Hippo signaling pathways consists of the Hippo protein kinase, which activates the Lats-Mob1 kinase.

B. The kinases are organized by a scaffolding molecule that, at least in budding and fission yeasts, targets the kinase cascade to centrosomes.

C. As in many kinase signaling cascades, a GTPase controls the activity of the mitotic exit network and the septation initiation network.

D. In metazoans, activation of the Hippo pathway leads to tissue overgrowth because the transcriptional activator TAZ (known as YAP in the mouse) constitutively promotes the expression of growth- and proliferation-promoting genes.

Which of the following statements are incorrect?

#Question id: 2978

#Unit 2. Cellular Organization

The most important regulatory control that restricts cyclins to the appropriate cell cycle stage is ubiquitin mediated, proteasome-dependent protein degradation. Which of the following statement is incorrect regarding to the degradation of protein?

#Question id: 2979

#Unit 2. Cellular Organization

Use the data in the accompanying table to answer the question. Minutes Spent in Cell Cycle Phases-

#Question id: 2980

#Unit 2. Cellular Organization

Following statements are regarding to the protein phosphatase Cdc14 function in budding yeast.

A. In budding yeast, the protein phosphatase Cdc14 throws the switch between two mutually antagonistic states during anaphase.

B. Cdc14 is kept inactive during most of the cell cycle, but is activated during anaphase by a GTPase signaling pathway known as the mitotic exit network.

C. Mitotic exit network is unresponsive to spindle position and becomes active in anaphase.

D. Cdc14 phosphatase activated by the activation of protein kinase cascade.

E. Cdc14 dephosphorylates APC/CCdh1 and Sic1 to promote mitotic cyclin degradation

and mitotic CDK inactivation, respectively. This process leads to exit from mitosis.

Which of the following combination is incorrect?

#Question id: 2981

#Unit 2. Cellular Organization

For the nuclear envelope to be broken down as cells go from prophase to prometaphase during mitosis, the nuclear lamina has to be disassembled. Which of the following statement is incorrect?