#Question id: 15413
#Unit 5. Developmental Biology
#Question id: 1387
#Unit 4. Cell Communication and Cell Signaling
The ability of a population of fibroblasts to migrate along the surface of a tissue culture dish depends on adhesion between the cell surface and the extracellular matrix molecules coating the dish. The dish is coated with laminin, and the only cell-surface protein capable of binding laminin is a cell-adhesion protein called an integrin. Integrins are integral plasma-membrane proteins that function as heterodimers. Under these conditions the rate at which a fibroblast can migrate along the laminin coated culture dish is proportional to the strength of adhesion between the cell and the laminin substrate. The table below lists the rate of cell migration observed for fibroblasts genetically engineered to generate the indicated phenotypes. Microinjection into the cytoplasm of a wild. type cell of a solution of a synthetic peptide possessing the same sequence as the integrin beta subunit cytoplasmic domain would be expected to yield an average fibroblast-cell migration rat
|
Fibroblast
Phenotype |
Level of
Integrin Heterodimer at the Cell Surface (percent of wild type) |
Rate of
Cell Migration (pm/min) |
|
1. Wild type |
100 |
2 |
|
2.
Overexpression of the wild-type integrin alpha subunit |
104 |
2 |
|
3. Overexpression
of an integrin beta subunit lacking the cytoplasmic domain |
96 |
0.6 |
|
4.
Overexpression of the soluble cytoplasmic domain of an integrin beta subunit |
98 |
0.6 |
|
5. Absence of
the integrin alpha subunit |
Less than 1 |
0.05 |
#Question id: 5383
#General Aptitude
12 yr ago the average age of a husband and a wife was 20 yr .The average remains the same today when they have two children. What is the present age of the youngest child if they differ in age by 2 yr.
#Question id: 2926
#Unit 2. Cellular Organization
Given below are some of the Mechanisms, checkpoint proteins and their functions.
Which of the following match is correct?
#Question id: 17811
#Unit 7. System Physiology – Animal