TLS Online TPP Program

#Question id: 32221


Which of the following statements is correct regarding mutations in the LDL receptor (LDLR) gene in patients with familial hypercholesterolemia?

#Unit 2. Cellular Organization
  1. Abolishes the ability of the LDL receptor to be incorporated into coated pits.
  2. Prevents the LDL receptor from properly folding in the endoplasmic reticulum, leading to its degradation.
  3. Disrupts the binding of LDL to the LDL receptor.
  4. Impairs the recycling of the LDL receptor, causing it to be degraded instead of being reused.