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#Question id: 7101


What is the mechanism by which cells fated to be mesoderm form in the marginal zone of the Xenopus embryo?

#Unit 5. Developmental Biology
  1. Cells in the marginal zone are fated to be mesoderm, but they do not become specified or determined as mesoderm until after they move internally during gastrulation.
  2. Cells of the vegetal region are induced by their proximity to the animal region cells to become mesoderm.
  3. Maternal factors packaged into the marginal zone act on these cells to instruct them to become mesoderm.
  4. Secreted signals of the TGF- family are released by the cells of the vegetal region and act on the adjacent cells of the marginal zone to instruct them to adopt a mesodermal fate.