TLS Online TPP Program

#Question id: 33153


Activation of APC/C depends primarily on association with one of two activating subunits (Cdc20 or Cdh1), because:

#Unit 2. Cellular Organization
  1. Their binding causes a conformational change that inhibit enzyme activity
  2. They provide the main binding site for the enzyme’s protein substrates
  3. They interact with short amino acid sequences on APC/C substrates, holding them in place while the APC/C builds degradation box on the target
  4. They provide help in the recognition of phosphorylated substrates