Which of the following situations would produce a Hill plot with n<  1.0?

(a) The protein has multiple subunits, each with a single ligand-binding site. Binding of ligand to one site decreases the binding affinity of other sites for the ligand.

(b) The protein is a single polypeptide with two ligand-binding sites, each having a different affinity for the ligand.

(c) The protein is a single polypeptide with a single ligand-binding site.

TLS Online TPP Program

#Question id: 19110

#Unit 8. Inheritance Biology

If the frequency of PKU among newborns is approximately 1/10,000 (when the parents are unrelated). What is the risk of a child with PKU if the parents are siblings?

TLS Online TPP Program

#Question id: 19111

#Unit 8. Inheritance Biology

If the frequency of PKU among newborns is approximately 1/10,000 (when the parents are unrelated). What is the risk of a child with PKU if the parents are uncle and niece?

TLS Online TPP Program

#Question id: 19112

#Unit 8. Inheritance Biology

the frequency of PKU among newborns is approximately 1/10,000 (when the parents are unrelated). What is the risk of a child with PKU if the parents are second cousins?

TLS Online TPP Program

#Question id: 19113

#Unit 8. Inheritance Biology

P, Q, and R are three different inbred, true-breeding strains of mice. A hybrid between P and Q is mated to R, and a hybrid between Q and R is mated to P. A male from the first mating is mated to a female from the second mating. What is the inbreeding coefficient of their progeny?

TLS Online TPP Program

#Question id: 19114

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:

                                       

Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR42 in Family 1.

TLS Online TPP Program

#Question id: 19115

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:

                

Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR43 in Family 1.