Which of the following situations would produce a Hill plot with n<  1.0?

(a) The protein has multiple subunits, each with a single ligand-binding site. Binding of ligand to one site decreases the binding affinity of other sites for the ligand.

(b) The protein is a single polypeptide with two ligand-binding sites, each having a different affinity for the ligand.

(c) The protein is a single polypeptide with a single ligand-binding site.

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#Question id: 12490

#Unit 8. Inheritance Biology

Tay-Sachs disease shows autosomal recessive inheritance. Parents of a newly diagnosed affected child are referred for genetic counselling. It would be correct to tell them that:

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#Question id: 12491

#Unit 8. Inheritance Biology

Phenylketonuria shows autosomal recessive inheritance with an incidence of 1 in 10000. Assume that the population is in Hardy-Weinberg equilibrium. Which of the following is correct?

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#Question id: 12492

#Unit 8. Inheritance Biology

A young man with phenylketonuria, who was successfully treated following diagnosis on newborn screening, is planning to start a family with his healthy, unaffected, and unrelated partner, who has no family history of phenylketonuria . Phenylketonuria shows autosomal recessive inheritance with an incidence of 1 in 10 000. Assume that the population is in Hardy-Weinberg equilibrium. Which of the following is correct?

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#Question id: 12493

#Unit 8. Inheritance Biology

Cystic fibrosis shows autosomal recessive inheritance with an incidence of 1 in 2500. The unaffected brother of an affected girl is referred for genetic counseling. Assume that the population is in Hardy-Weinberg equilibrium. Which of the following is correct?

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#Question id: 12494

#Unit 8. Inheritance Biology

Hunter syndrome is a rare form of mucopolysacchararidosis that differs from all other forms in that it shows X-linked recessive inheritance. A woman with two affected brothers is referred for genetic counselling. Which of the following is correct?

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#Question id: 12495

#Unit 8. Inheritance Biology

Haemophilia A is a severe coagulation disorder that shows X-linked recessive inheritance. Red-green colour blindness also shows X-linked recessive inheritance. A man with both haemophilia A and colour blindness is referred for genetic counseling. Assume that his partner is not a carrier of either of these conditions. Which of the following is correct?