Which of the following situations would produce a Hill plot with n<  1.0?

(a) The protein has multiple subunits, each with a single ligand-binding site. Binding of ligand to one site decreases the binding affinity of other sites for the ligand.

(b) The protein is a single polypeptide with two ligand-binding sites, each having a different affinity for the ligand.

(c) The protein is a single polypeptide with a single ligand-binding site.

#Question id: 4480

#Unit 3. Fundamental Processes

The reason for TBP’s unorthodox recognition mechanism is

#Question id: 4481

#Unit 3. Fundamental Processes

Choose correct statements about recognition mechanism of TBP ;

A. TBP causes the minor groove to be widened to an almost flat conformation

B. It also bends the DNA by an angle of ~120o

C. The interaction between TBP and DNA involves maximum number of hydrogen bonds between the protein and the edges of the base.

D. Much of the specificity is imposed by two pairs of phenylalanine side chains that intercalate between the base pairs at either end of the recognition sequence and drive the strong bend in the DNA.

#Question id: 4482

#Unit 3. Fundamental Processes

The General Transcription Factors of RNA Polymerase, with their subunits, select correct matching

#Question id: 4483

#Unit 3. Fundamental Processes

TAF42 and TAF62 from Drosophila form a structure similar to that of the

#Question id: 4484

#Unit 3. Fundamental Processes

Match General Transcription Factors with their functions;

#Question id: 4485

#Unit 3. Fundamental Processes

In multicellular organisms, regulatory sequences can spread thousands of nucleotides from the promoter—both upstream and downstream—and can be made up of tens of regulator binding sites. Often, these binding sites are grouped in units called_?