In case of Coiled-coils 

a. Alpha-helices are packed together through the charged interactions only

b. They have heptad repeated sequences.

c. 3.6 aa / turn and 5.2A for a helix. 

d. abcdefg 'a' &'d’ are hydrophobic residues 'e' and 'g' are found to be charged amino.

Which of the following is correct

TLS Online TPP Program

#Question id: 33355

#Unit 1. Molecules and their Interaction Relevant to Biology

Which statement stands incorrect

TLS Online TPP Program

#Question id: 33356

#Unit 1. Molecules and their Interaction Relevant to Biology

Hemoglobin undergoes substantial changes in quaternary structure on oxygen binding: the a1b1 and a2b2 dimers rotate with respect to each other by

TLS Online TPP Program

#Question id: 33357

#Unit 1. Molecules and their Interaction Relevant to Biology

Protein A has a binding site for ligand X with a Kd of 10^-6 µM. Protein B has a binding site for ligand X with a Kd of 10^-9 µM. Which statement is incorrect?

TLS Online TPP Program

#Question id: 33358

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following situations would produce a Hill plot with n<  1.0?

(a) The protein has multiple subunits, each with a single ligand-binding site. Binding of ligand to one site decreases the binding affinity of other sites for the ligand.

(b) The protein is a single polypeptide with two ligand-binding sites, each having a different affinity for the ligand.

(c) The protein is a single polypeptide with a single ligand-binding site.

TLS Online TPP Program

#Question id: 33359

#Unit 1. Molecules and their Interaction Relevant to Biology

The protein calcineurin binds to the protein calmodulin with an association rate of 8.9 X10³ M^-1s^-1 and an overall dissociation constant, Kd, of 10 nM. The dissociation rate, kd

TLS Online TPP Program

#Question id: 33360

#Unit 1. Molecules and their Interaction Relevant to Biology

a. HbS (sickle-cell Hb): substitutes a Val for a Glu on the surface

b. Hb Cowtown: eliminates an ion pair involved in T-state stabilization

c. Hb Memphis: substitutes one uncharged polar residue for another of similar size on the surface

d. Hb Bibba: substitutes a Pro for a Leu involved in an α helix

Which Hb variant least likely to cause pathological symptoms