TLS Online TPP Program

#Question id: 7128


Imagine that in an attempt to get the â-globin gene to be expressed in B-cells, the transcription factors (GATA-1 and GATA-2) known to control the â-globin gene in erythrocytes were introduced into B-cells, yet the â-globin gene was not expressed. What is a likely explanation for this result?

#Unit 5. Developmental Biology
  1. The erythrocyte transcription factors are degraded rapidly in the B-cell, and so cannot act on the â-globin gene.
  2. The â-globin gene in the B-cells is packaged into heterochromatin, and the erythrocyte transcription factors are insufficient to remodel that chromatin into an active state.
  3. Erythrocyte transcription factors cannot interact with their target DNA sequences in B-cells, even though those sequences are present and accessible.
  4. Even though the necessary erythrocyte-specific transcription factors are now present in the B-cells, the general transcription factors required for â-globin gene expression would not be present