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#Question id: 7132

What happens if you introduce the gene myoD into fibroblast cells growing in culture?

#Unit 5. Developmental Biology
  1. The fibroblasts will express muscle-specific proteins, fuse, and form functional muscle in culture.
  2. Nothing will happen because fibroblasts are derived from a different cell population in the embryo than are the muscle precursors that respond to myoD.
  3. The fibroblasts will undergo apoptosis, due to the abnormal effects of myoD on their normal differentiation.
  4. myoD will activate expression of myogenin, but the muscle-specific genes will not be able to activate.
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TLS Online TPP Program

#Question id: 12505

#Unit 8. Inheritance Biology

The marker genotype for I 2 must have been:
TLS Online TPP Program

#Question id: 12506

#Unit 8. Inheritance Biology

Using the linked markers III 3 can be told that:
TLS Online TPP Program

#Question id: 12507

#Unit 8. Inheritance Biology

In this pedigree I 1 and II 2 have Becker muscular dystrophy which shows X-linked recessive inheritance. III 2 has oculocutaneous albinism which shows autosomal recessive inheritance with an incidence in the general population of 1 in 10 000. The disease status for both Becker muscular dystrophy and oculocutaneous albinism is unknown for IV 1 and IV 2.
What is the probability that III 3 is a carrier of Becker muscular dystrophy?
TLS Online TPP Program

#Question id: 12508

#Unit 8. Inheritance Biology

In this pedigree I 1 and II 2 have Becker muscular dystrophy which shows X-linked recessive inheritance. III 2 has oculocutaneous albinism which shows autosomal recessive inheritance with an incidence in the general population of 1 in 10 000. The disease status for both Becker muscular dystrophy and oculocutaneous albinism is unknown for IV 1 and IV 2.
What is the probability that III 3 is a carrier of oculocutaneous albinism?
TLS Online TPP Program

#Question id: 12509

#Unit 8. Inheritance Biology

In this pedigree I 1 and II 2 have Becker muscular dystrophy which shows X-linked recessive inheritance. III 2 has oculocutaneous albinism which shows autosomal recessive inheritance with an incidence in the general population of 1 in 10 000. The disease status for both Becker muscular dystrophy and oculocutaneous albinism is unknown for IV 1 and IV 2.
What is the probability that IV 1 is a carrier of oculocutaneous albinism? 
TLS Online TPP Program

#Question id: 12510

#Unit 8. Inheritance Biology

In this pedigree I 1 and II 2 have Becker muscular dystrophy which shows X-linked recessive inheritance. III 2 has oculocutaneous albinism which shows autosomal recessive inheritance with an incidence in the general population of 1 in 10 000. The disease status for both Becker muscular dystrophy and oculocutaneous albinism is unknown for IV 1 and IV 2.
What is the probability that IV 2 will be affected with Becker muscular dystrophy?