TLS Online TPP Program

#Question id: 7135


Recently, it was reported that adult, differentiated cells can be made to behave as pluripotent stem cells by the introduction of a few genes, one of which was Oct4. What was the rationale for this experiment?

#Unit 5. Developmental Biology
  1. Oct4 expression is one of the requisites for the maintenance of pluripotent embryonic stem cells in culture.
  2. the Oct4 gene produces a cell-cell signaling protein that is used by stem cells to stimulate cell division
  3. Oct4 is only expressed in embryonic stem cells, and so its expression automatically reverses any differentiation that may have gone on in a cell
  4. the Oct4 gene is lost from differentiated cells through a genomic rearrangement, and its reintroduction reverses that rearrangement and hence differentiation