Find true and false statements

A. Comparisons of related genes in different species show that the sequences of the corresponding exons are usually conserved

B. when two genes are related, the relationship between their exons is closer than the relationship between their introns.

C. The sequences of the introns are much less similar.

D. Introns evolve much more rapidly than exons because of the lack of selective pressure to produce a polypeptide with a useful sequence.

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#Question id: 1261

#Unit 4. Cell Communication and Cell Signaling

A FOXO3a mutant in which the three serine residues that are targets for PKB are mutated to alanine then what will be the result?

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#Question id: 1262

#Unit 4. Cell Communication and Cell Signaling

Although MAP kinase is often activated in multicellular animals by RTKs or cytokine receptors, signaling from other receptors can activate MAP kinase in other eukaryotic cells. we consider the mating pathway in the yeast S. cerevisiae, a well-studied example of a MAP kinase cascade linked to G protein–coupled receptors (GPCRs). Which of the following statement is incorrect?

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#Question id: 13159

#Unit 4. Cell Communication and Cell Signaling

How signaling is involved in ensuring that yeast cells fuse only with cells of the opposite mating type?

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#Question id: 13160

#Unit 4. Cell Communication and Cell Signaling

According to the Switching mechanism, monomeric G proteins exist in two states. Match the following states (Column I) with correct mechanism (Column II).

Column I	Column II
A. “ON” state	i. switch I and switch II, are bound to the terminal γ phosphate of GTP through interactions with the backbone amide groups of conserved threonine and glycine residues.
B. “OFF” state	ii. GTPase-activating proteins
	iii. guanine nucleotide exchange factor
	iv. Due to the removal of the γ phosphate by GTPase-catalyzed hydrolysis causes switch I and switch II to relax into a different conformation

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#Question id: 13161

#Unit 4. Cell Communication and Cell Signaling

Which of the following mechanism depends on the activation of heterotrimeric G proteins?

TLS Online TPP Program

#Question id: 13162

#Unit 4. Cell Communication and Cell Signaling

In the amoeba Dictyostelium discoideum, cAMP acts as an extracellular signalling molecule and binds to and signals via a G protein–coupled receptor; it is not a second messenger. Amoeba cells were transfected with genes encoding two fusion proteins: a Gα fused to cyan fluorescent protein (CFP), and a Gβ fused to yellow fluorescent protein (YFP). CFP normally fluoresces 490-nm light; YFP, 527-nm light. In which conditions fluorescence

energy transfer occur from CFP to YFP?