Practice Questions

TLS Online TPP Program

#Question id: 34120

The dynamic nature of DNA binding to the histone core structure is important, because many DNA-binding proteins strongly prefer to bind to histone-free DNA. Such proteins can recognize their binding site only when it is released from the histone octamer or is contained in linker or nucleosome-free DNA.

Which of the following statement stands untrue for above fact

#Unit 2. Cellular Organization

DNA-binding site for a given protein on nucleosome can be found anywhere on wrapped DNA
A binding site near position 73 of the 147 bp tightly associated with a nucleosome is rarely accessible.
Binding sites near the ends (position 1 or 147) of the nucleosomal DNA are most frequently accessible.
Mechanism of exposure is due to unwrapping of the DNA from the nucleosome, rather than to the DNA briefly coming off the surface of the histone octamer