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#Question id: 34137


Which of the following best explains why glucose uptake into liver cells continues in insulin-resistant states, even when skeletal muscle glucose uptake is impaired?

#Unit 7. System Physiology – Animal
  1. Liver cells express GLUT-4 transporters, which are activated by AMP-activated protein kinase (AMPK) during fasting.
  2. Liver cells use GLUT-2 transporters, which are insulin-dependent and respond to glucokinase activation.
  3. Liver cells express GLUT-2 transporters, which are insulin-independent and facilitate passive glucose uptake based on concentration gradient.
  4. Glucokinase in liver cells directly increases the number of GLUT-4 transporters in the plasma membrane, enhancing glucose uptake.