TLS Online TPP Program

#Question id: 34168


Angiotensin II stimulates aldosterone production in the zona glomerulosa by binding to AT1 receptors. Which of the following best describes the intracellular signaling pathway and its role in aldosterone biosynthesis?

#Unit 7. System Physiology – Animal
  1. AT1 activates cAMP via Gs protein, enhancing 11β-hydroxylase activity for cortisol synthesis
  2. AT1 activates adenylyl cyclase, increasing cAMP and PKA, which upregulates LDL receptor expression
  3. AT1 signals through Gq, activating phospholipase C, which increases PKC activity and promotes aldosterone synthase function
  4. AT1 signals via Gi protein to inhibit cAMP and reduce cortisol feedback, indirectly promoting aldosterone release