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#Question id: 7186


In dictyostelium stalk and spore cell maturation depends on cAMP level. Which of the following statement is incorrect regarding to this process?

#Unit 5. Developmental Biology
  1. During spore formation, ACG localizes to the spore surface when the prespore vesicles fuse with the plasma membrane. The cAMP phosphodiesterase RegA also plays a crucial role in regulating intracellular cAMP levels.
  2. This process is mediated by socalled sensor histidine kinases/phosphatases which either phosphorylate or dephosphorylate themselves on a histidine residue when a signal molecule binds to their sensor domain.
  3. Ammonia inhibits the onset of fruiting body formation and stalk maturation, activates the histidine phosphatase activity of sensor histidine phophatase C (DhkC), resulting in RegA activation, hydrolysis of cAMP and inhibition of PKA activity.
  4. Spore differentiation factor 2 (SDF-2) activates the histidine phosphatase activity of DhkA (histidine phosphatase A), which results in the inactivation of RegA, the accumulation of cAMP and in PKA activation, which subsequently causes spore maturation.