Following statements regarding to feedback loops during limb development.

A. When the limb bud is relatively small, an initial positive feedback loop is established between Fgf10 produced in the mesoderm and Fgf8 produced in the ectoderm, promoting limb outgrowth.

B. As the limb bud grows, the ZPA is established, and another regulatory loop is created by inhibiting the BMP in mesoderm and maintain FGF expression.

C. In anterior region of the limb bud, Fgf8 positively regulates Etv4/5, which in turn repress Shh in this region, further reinforcing the posterior-to-anterior gradient of Shh from the ZPA.

D. In posterior region of the limb bud, Fgf8 positively regulates Etv4/5, which in turn repress Shh in this region, further reinforcing the posterior-to-anterior gradient of Shh from the ZPA.

Which of the following combinations are incorrect?

  

TLS Online TPP Program

#Question id: 28669

#Unit 2. Cellular Organization

Fission yeast cells carrying a CDK1 mutation in which the tyrosine-15 residue is replaced by phenylalanine, what will cause from this mutation?

a) Shows larger than normal cells

b) Shows smaller than normal cells

c) allows the phosphorylation of phenylalanine and normal cell activation are seen

d) premature mitotic CDK activation and entry into mitosis

TLS Online TPP Program

#Question id: 28670

#Unit 2. Cellular Organization

In fission yeast cells carrying a CDK1 mutation in which the tyrosine-15 residue is replaced by other amino acid which is?

TLS Online TPP Program

#Question id: 28671

#Unit 2. Cellular Organization

 In which of the following condition premature mitotic CDK activation and premature entry into mitosis are seen? 

a) during the activity of dual-specificity phosphatases

b) during replacing the tyrosine-15 residue from phenylalanine

c) defective wee1+ gene

TLS Online TPP Program

#Question id: 28672

#Unit 2. Cellular Organization

Which proteins is involved to inhibit Cdc25 phosphatase and hold it into inactive condition

TLS Online TPP Program

#Question id: 28673

#Unit 2. Cellular Organization

Which protein activity involve to facilitate the activating an initial small pool of cyclin B/1 at the centrosome and also facilitate centrosome Maturation?

TLS Online TPP Program

#Question id: 28674

#Unit 2. Cellular Organization

Which of the following cyclin-CDKs involve to phosphorylate Cdc25C for the stimulation of its phosphatase activity ?