Following statements are related to the Epigenetic regulation of Hox gene expression in the chick limb .

A. Hoxa13 is normally not expressed during early limb bud outgrowth.

B. Hoxa13 is normally expressed during early limb bud outgrowth.

C. Inhibition of histone deacetylases with a TSA-coated bead implanted into the early limb bud results in precocious Hoxa13 expression and specifically reduced skeletal elements of the zeugopod

D. Inhibition of HAT proteins with a TSA-coated bead implanted into the early limb bud results in Hoxa13 expression and specifically reduced skeletal elements of the zeugopod

E. The epigenetic hold on gene Hoxa13 expression to allow the necessary time for zeugopod development.

F. The epigenetic hold on gene Hoxa13 expression to allow the necessary time for autopod development.

Which of the following combinations are correct?

TLS Online TPP Program

#Question id: 26528

#Unit 3. Fundamental Processes

Which of the following statement is true regarding RNA polymerase III

1.RNA polymerase III transcribes a set of short genes

2.The classical class III genes (types I and II) have promoters that lie wholly within the genes.

3.Box A and Box B is the characteristics of RNA polymerase III type II

4.Box A and Box B is the characteristics of RNA polymerase III type I

TLS Online TPP Program

#Question id: 26529

#Unit 3. Fundamental Processes

RNA Polymerase III promoters are bipartite, which of the following is correctly representing the binding transcriptional factor with their location

TLS Online TPP Program

#Question id: 26530

#Unit 3. Fundamental Processes

Which of the following statement is correct

1.Start point, is the first base of mRNA to be A

2.Initiator (Inr) is Py2CAPy5, where Py stands for any pyrimidine. The Inr is contained between positions -3 and +5.

3.TATA box, usually located, 25 bp upstream in its location at -25 in eukaryotes 

4.The exception is in yeast, where the TATA box is more typically found at -90.

TLS Online TPP Program

#Question id: 26531

#Unit 3. Fundamental Processes

TATA less, Inr Less promoters uses ……….as activator to position TBP with TAFs

TLS Online TPP Program

#Question id: 26532

#Unit 3. Fundamental Processes

Sp1 (Mr  80,000) is a transcription activator for a large number of genes in higher eukaryotes. Its DNA binding site, the GC box having consensus sequence

TLS Online TPP Program

#Question id: 26533

#Unit 3. Fundamental Processes

Which of the following is incorrect about Sp1