TLS Online TPP Program

#Question id: 7242


The cells of  posterior marginal zone act as the equivalent of the amphibian Nieuwkoop center because:

A. once the PMZ has formed, it controls the other regions of the margin.

B. Cells of PMZ initiate other regions of the margin from forming their own primitive streaks.

C. the entire marginal zone produces Wnt8c (capable of inducing the accumulation of -catenin) and secrete Vg1, a member of the TGF-family.

D. The PMZ cells secretes nodal protein and Nodal activity is needed to initiate the primitive streak.

E. When placed in the anterior region of the marginal zone, a graft of PMZ tissue (posterior to and including Koller’s sickle) is able to induce wnt signaling.

Which of the following option is correct?

#Unit 5. Developmental Biology
  1. A only
  2. B, C and D
  3. A, C and E
  4. C only