TLS Online TPP Program

#Question id: 7254


Following statements regarding to the micromeres specification and regulatory input  in sea urchin embryo. Which of the following statement is correct?

#Unit 5. Developmental Biology
  1. OTX is a general transcription factor, and β-catenin from the maternal cytoplasm is concentrated at the vegetal pole of the egg. These transcriptional regulators are inherited by the macromeres and activate the Pmar1 gene.
  2. Pmar1 encodes a repressor of HesC, which in turn encodes activator of several genes involved in micromere specification.
  3. In the veg2 cells, Pmar1 is not activated and the HesC gene product shuts down the non-skeletogenic genes.
  4. As soon as the micromeres form, maternal β-catenin and Otx activate the Blimp1 gene, whose product activates the Wnt8 gene. Wnt8 protein is then received by the same micromeres that made it (i.e., autocrine regulation), activating the micromeres’ own genes for β-catenin.