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TLS Online TPP Program

#Question id: 7264

The Dictyostelia social amoebas are found in a wide range of soil habitats. They can come together to form a fruiting structure, in which a proportion of cells are sacrificed to build the stalk and the remainder differentiate into resilient dormant spores. This multicellular life cycle is common to all Dictyostelids. It consists of an interconnected programme of cell movement and cell differentiation, and has been intensively studied in the model organism D. discoideum. Few mutants (Column A) and phenotypes (Column B) are listed in the table given below.

    Column A

    Column B

A. Loss of function of cAMP-dependent protein kinase (PKA)

i. cell develop normally but unable to germinate

B. Loss of function of RegA

ii. Loose aggregate form

C. Loss of function of adenylate cyclase B

iii. No aggregation

D. Loss of function of gp80

iv. accumulation of cAMP and PKA activation

 Match the correct mutant with the observed phenotype.

#Unit 5. Developmental Biology
  1. A-iv, B-ii, C-iii, D-i
  2. A-iv, B-iii, C-i, D-ii
  3. A-ii, B-iii, C-iv, D-i
  4. A-iii, B-iv, C-i, D-ii
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TLS Online TPP Program

#Question id: 27949

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following reaction is catalyzed by enzyme phosphohexose isomerase (phosphoglucose isomerase)
TLS Online TPP Program

#Question id: 27950

#Unit 1. Molecules and their Interaction Relevant to Biology

Some of the properties of Hexokinases I, II, III & IV is given

a. Hexokinases I, II, and III shows hyperbolic curve of glucose binding while Hexokinase IV shows sigmoidal curve 

b. Accumulation of glucose 6-phosphate inhibits hexokinases I–III by feedback mechanism 

c. Accumulation of glucose 6-phosphate allosterically inhibits hexokinases I–III.

d. The allosteric effector of Hexokinase IV is fructose 6-phosphate.

Which of the following is incorrect  
TLS Online TPP Program

#Question id: 27951

#Unit 1. Molecules and their Interaction Relevant to Biology

Fructose 6-phosphate + ATP phosphate  → Fructose 1,6-bisphosphate + ADP bisphosphate + ADP
a.This is a second priming reaction of glycolysis 
b. This reaction can be inhibited by increasing the concentration of citrate and ATP
c. This reaction can be inhibited by increasing the concentration ADP, AMP & F2,6BP
d. This reaction can be activated by increasing the concentration ADP, AMP & F2,6BP

Choose the correct option regarding the given reaction
TLS Online TPP Program

#Question id: 27952

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following given set of condition will favours gluconeogenesis
TLS Online TPP Program

#Question id: 27953

#Unit 1. Molecules and their Interaction Relevant to Biology

[F26BP] concentration are related to the glycolysis, and gluconeogenesis

a.↑[F26BP] Stimulates glycolysis, and gluconeogenesis

b.↓ [F26BP] Inhibits glycolysis, and gluconeogenesis

c.↑ [F26BP] Stimulates glycolysis, inhibits gluconeogenesis

d↓ [F26BP] Inhibits glycolysis, stimulates gluconeogenesis

Select the condition of [F26BP] in which appropriate process will takes place 
TLS Online TPP Program

#Question id: 27954

#Unit 1. Molecules and their Interaction Relevant to Biology

Some of the statement is given regarding the Pyruvate kinase 
a. Pyruvate kinase is activated  by ATP, acetyl-CoA, long-chain fatty acids 
b. Pyruvate kinase is allosterically inhibited by ATP, acetyl-CoA, long-chain fatty acids
c. Accumulation of alanine allosterically inhibits pyruvate kinase M in muscles, slowing the production of pyruvate by glycolysis
d. Accumulation of alanine activate pyruvate kinase M in muscles, increases the production of pyruvate by glycolysis

Which of the following is incorrect