TLS Online TPP Program

#Question id: 7267


Endocrine disruptors can interfere with hormone function in many ways like, They can act as antagonists and inhibit the binding of a hormone to its receptor or block the synthesis of a hormone. which of the following example best explains the antagonistic effect of endocrine disruptors?

#Unit 5. Developmental Biology
  1. The endocrine disruptor diethylstilbestrol (DES), which binds to the estrogen receptor and mimics estradiol, a hormone that is very active in building the tissues of the female reproductive tract.

  2. DDE, a metabolic product of the insecticide DDT, can act as an anti-testosterone, binding to the androgen receptor and preventing normal testosterone from functioning properly.
  3. The herbicide atrazine, elevates the synthesis of estrogen and can convert testes into ovaries in frogs.
  4. Polychlorinated biphenyls (PCBs) disrupt the endocrine system is by interfering with the elimination and degradation of thyroid hormones.