TLS Online TPP Program

#Question id: 629


In the presence of a fixed concentration of a competitive inhibitor, which of the following would best characterize an enzyme-catalyzed reaction when the concentration of the substrate is increased?

#Unit 1. Molecules and their Interaction Relevant to Biology
  1. The inhibition does not change.

  2. The inhibition decreases.

  3. The Km increases.

  4. The maximal rate of reaction (V max) increases.

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TLS Online TPP Program

#Question id: 857

#Unit 1. Molecules and their Interaction Relevant to Biology

The aggregation of nonpolar side chains in the interior of a protein is favored by

TLS Online TPP Program

#Question id: 858

#Unit 1. Molecules and their Interaction Relevant to Biology

Unfolded protein response (UPR)

TLS Online TPP Program

#Question id: 859

#Unit 1. Molecules and their Interaction Relevant to Biology

Which one statement is incorrect about ATG genes;

TLS Online TPP Program

#Question id: 860

#Unit 1. Molecules and their Interaction Relevant to Biology

Select true ‘T’ AND false ‘F’ about ubiquitinylation

I. These ubiquitin-like modifiers control processes as diverse as nuclear import,

II. Regulated by the ubiquitin-like modifier Sumo, and autophagy,

III. Regulated by the ubiquitin-like modifier Atg8.

IV. For a protein to be efficiently degraded, it must be linked to a chain of at least four tandemly linked ubiquitin molecules in which Lys 34 of each ubiquitin forms an isopeptide bond with the C-terminal carboxyl group of the following ubiquitin.

TLS Online TPP Program

#Question id: 861

#Unit 1. Molecules and their Interaction Relevant to Biology

Alexander Varshavsky discovered, the half-lives of many cytoplasmic proteins vary with the identities of their N-terminal residues via the so-called N-end rule:-

A. Destabilizing N-terminal residues Asp, Arg, Leu, Lys, and Phe have half-lives of

i. Only 2 to 3 minutes,

B. Stabilizing N-terminal residues Ala, Gly, Met, Ser, Thr, and Val have half-lives of

ii. >10 hours in prokaryotes

iii. >20 hours in eukaryotes.

TLS Online TPP Program

#Question id: 862

#Unit 1. Molecules and their Interaction Relevant to Biology

Match the following

lysosomal protein degradation pathways

         Found in

1. Nonselective

a-well-nourished cells

i-containing the pentapeptide Lys-Phe-Glu-Arg-Gln

2- Selective

b-starving cells