TLS Online TPP Program

#Question id: 21434


A profile can be generated from a multiple sequence alignment by obtaining position specific preference (or probability) of each amino acid. This can be used to identify homologs. However, the key difference between a profile alignment like this and Hidden Markov Model (HMM) is:

#Unit 11. Bioinformatics
  1. HMM can find more remote homologs using PSIBLAST
  2. HMM does not generate a profile of position specific probabilities
  3. HMM has the option to introduce gaps with position specific gap penalties
  4. HMM is independent of a multiple sequence alignment