TLS Online TPP Program

#Question id: 10191


Statements are given as
A. Primary kinetic isotope effects are rate changes due to isotopic substitution at a site of bond breaking in the rate determining step of a reaction.
B. Solvent shows primary kinetic isotope effect
C. Secondary kinetic isotope effects are rate changes due to isotopic substitutions at a site other than the bond breaking site in the rate determining step of the reaction.
D. Solvent shows primary kinetic isotope effect and secondary kinetic effect as well
Which of the following is correct combination of statements

#Unit 1. Molecules and their Interaction Relevant to Biology
  1. A & B
  2. A & C
  3. B & D
  4. A, B & C
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TLS Online TPP Program

#Question id: 2583

#Unit 2. Cellular Organization

Following statements are regarding to the microtubules.

A. Tubulin is the major structural component of microtubules

B. Microtubule-associated proteins (MAPs) associate with tubulin and help mediate the assembly, dynamics, and function of microtubules.

C. Free tubulin exists as a dimer in which the α-subunit contains a trapped and hydrolyzable GTP and theβ-subunit binds an exchangeable and nonhydrolyzable GTP

D. All microtubules are nucleated from microtubule-organizing centers (MTOCs), and many remain anchored with their (−) ends there. Thus the end away from the MTOC is always the (+) end.

Which of the following statements is incorrect?

TLS Online TPP Program

#Question id: 2584

#Unit 2. Cellular Organization

The polymerization of pure G-actin in vitro proceeds in three phases.

    Column I

   Column II

A. nucleation phase

i. G-actin monomers exchange with subunits at the filament ends, but there is no net change in the total length of filaments

B. elongation phase

ii. marked by a lag period in which G-actin subunits combine into an oligomer of two or three subunits

C. steady-state phase

iii. the short oligomer rapidly increases in length by the addition of actin monomers to

both of its ends

Which of the following represent correct match?

TLS Online TPP Program

#Question id: 2585

#Unit 2. Cellular Organization

Which of the following is the correct sequence that describes the excitation and contraction of a skeletal muscle fiber?

A. Tropomyosin shifts and unblocks the cross-bridge binding sites.

B. Calcium is released and binds to the troponin complex.

C. Transverse tubules depolarize the sarcoplasmic reticulum.

D. The thin filaments are ratcheted across the thick filaments by the heads of the myosin molecules using energy from ATP.

E. An action potential in a motor neuron causes the axon to release acetylcholine, which depolarizes the muscle cell membrane.

TLS Online TPP Program

#Question id: 2585

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is the correct sequence that describes the excitation and contraction of a skeletal muscle fiber?

A. Tropomyosin shifts and unblocks the cross-bridge binding sites.

B. Calcium is released and binds to the troponin complex.

C. Transverse tubules depolarize the sarcoplasmic reticulum.

D. The thin filaments are ratcheted across the thick filaments by the heads of the myosin molecules using energy from ATP.

E. An action potential in a motor neuron causes the axon to release acetylcholine, which depolarizes the muscle cell membrane.

TLS Online TPP Program

#Question id: 2586

#Unit 2. Cellular Organization

Intermediate filaments are the only nonpolar fibrous component of the cytoskeleton and are not associated with motor proteins. Intermediate filaments are built from coiled coil dimers that associate in an antiparallel fashion into tetramers and then into protofilaments, 16 of which make up the filament. There are five major classes of intermediate filament proteins. Match the following proteins (Column I) with their class (Column II).

Column I

Column II

A. Lamins

a. Class I

B. Keratins

b. Class II

C. Desmin

c. Class III

D. Neurofilaments

d. Class IV

e. Class V

Which of the following is correct?

TLS Online TPP Program

#Question id: 2588

#Unit 2. Cellular Organization

Which of the following statement is correct regarding attachment of microtubule to the kinetochore?