TLS Online TPP Program

#Question id: 718


Poly- L -leucine in an organic solvent such as dioxane is a helical, whereas poly- L isoleucine is not. Why do these amino acids with the same number and kinds of atoms have different helix-forming tendencies?

#Unit 1. Structure and Function of Biomolecules
  1. Leucine has bulky side chain than isoleucine so it forms helix.

  2. Methyl group at γ position of isoleucine cause stearic hindrance and blocks helix formation tendency

  3. Due to the stearic hindrance caused by β carbon- methyl group, isoleucine can’t form helix. Methyl group at γ position of isoleucine cause stearic hindrance and blocks helix formation tendency.

  4. Isoleucine has chiral carbon due to which it can,t form poly-L isoleucine helix.

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TLS Online TPP Program

#Question id: 41072

#Unit 8. Inheritance Biology

Q.Which of the following scenarios is a dominant-negative mutation most likely to be observed?

TLS Online TPP Program

#Question id: 41073

#Unit 8. Inheritance Biology

Q. A researcher is studying a novel receptor kinase involved in cell signaling. The functionally active form of this receptor is a homodimer that forms at the cell membrane upon ligand binding. The researcher isolates a mutant allele that produces a structurally altered, kinase-dead version of the receptor. When a heterozygous cell line (carrying one normal allele and one mutant allele) is generated, signaling is almost completely abolished, mimicking a null phenotype. Biochemical analysis reveals that the mutant protein is stably expressed and still binds to the normal protein.
which of the following best explains this observation?

TLS Online TPP Program

#Question id: 41074

#Unit 8. Inheritance Biology

Q. What is the primary advantage of utilizing conditional mutants in genetic research?

TLS Online TPP Program

#Question id: 5687

#Unit 8. Inheritance Biology

The error in meiosis that produces a 47,XYY karyotype is best  described by

TLS Online TPP Program

#Question id: 5688

#Unit 8. Inheritance Biology

Which of the following are not cause of aneuploidy

TLS Online TPP Program

#Question id: 5689

#Unit 8. Inheritance Biology

What kind of aneuploidy gamete will be generated if meiotic nondisjuction in second division (n represent haploid number of chromosome )