#Question id: 11781
#Unit 7. System Physiology – Animal
A 40-year-old woman comes to the emergency room with a fracture in the neck of the femur. Radiographs reveal generalized demineralization of the bone in the area. Her plasma calcium ion concentration is significantly greater than normal: 12.2 mg/dL. Which of the following conditions is consistent with this presentation?
#Question id: 19789
#Unit 13. Methods in Biology
#Question id: 14810
#Unit 4. Cell Communication and Cell Signaling
#Question id: 7173
#Unit 5. Developmental Biology
Normally, the FgfR3 protein (a receptor tyrosine kinase) is activated by a fibroblast growth factor and signals the chondrocytes to stop dividing and begin differentiating into cartilage. This signal is mediated by the Stat protein, which is phosphorylated by activated FgfR3 and then translocated into the nucleus. Inside the nucleus, Stat activates the genes encoding a cell cycle inhibitor, the p21 protein. The mutation in FgfR3 causes the lethal condition thanatophoric dysplasia. This condition may be achieved by:
A. Mutations in the extracellular domain of the FgfR3 protein
B. Mutations in the tyrosine kinase intracellular domain of the FgfR3 protein
C. Mutations in the transmembrane domain of the FgfR3 protein
Which of the following is correct?
#Question id: 32142
#Unit 1. Molecules and their Interaction Relevant to Biology