Ramachandran plots can help increase the accuracy of models derived from x-ray crystallography data. The plot below was created by measuring phi, and psi for each amino acid residue in a 2.2 A resolution crystal structure. In the plot, which excludes Gly and Pro residues, selected residues (dots) are numbered 1 through 5.

Which of the following statements can be correctly stated for this plot in reference to selected residues?

A. Residues 1 and 3 are in either B sheets

B. residue 2 is in a right-handed a helix, and residue 4 is in a left-handed a helix.

C. If residue 5 were Gly, it might be in an acceptable position in the plot

#Question id: 858

#Unit 1. Molecules and their Interaction Relevant to Biology

Unfolded protein response (UPR)

#Question id: 859

#Unit 1. Molecules and their Interaction Relevant to Biology

Which one statement is incorrect about ATG genes;

#Question id: 860

#Unit 1. Molecules and their Interaction Relevant to Biology

Select true ‘T’ AND false ‘F’ about ubiquitinylation

I. These ubiquitin-like modifiers control processes as diverse as nuclear import,

II. Regulated by the ubiquitin-like modifier Sumo, and autophagy,

III. Regulated by the ubiquitin-like modifier Atg8.

IV. For a protein to be efficiently degraded, it must be linked to a chain of at least four tandemly linked ubiquitin molecules in which Lys 34 of each ubiquitin forms an isopeptide bond with the C-terminal carboxyl group of the following ubiquitin.

#Question id: 861

#Unit 1. Molecules and their Interaction Relevant to Biology

Alexander Varshavsky discovered, the half-lives of many cytoplasmic proteins vary with the identities of their N-terminal residues via the so-called N-end rule:-

#Question id: 862

#Unit 1. Molecules and their Interaction Relevant to Biology

Match the following

#Question id: 863

#Unit 1. Molecules and their Interaction Relevant to Biology

Ubiquitinated proteins are proteolytically degraded in an ATP-dependent process mediated by a large (∼2500 kD, 26S) multiprotein complex named the 26S proteasome;