TLS Online TPP Program

#Question id: 733


Which one of the statements on protein conformation, detailed below is INCORRECT?

#Unit 1. Structure and Function of Biomolecules
  1. All types of B turns exist with both positive and negative dihydral angle values.

  2. PPII or PGII helix are found in proteins but they are not considered as equivalent secondary structure elements.

  3. Dihydral angles of extended peptide chain exist near 0o point in Ramachandran plot.

  4. PPII helices are stabilized by main chain-water hydrogen bonds

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TLS Online TPP Program

#Question id: 858

#Unit 1. Structure and Function of Biomolecules

Unfolded protein response (UPR)

TLS Online TPP Program

#Question id: 859

#Unit 1. Structure and Function of Biomolecules

Which one statement is incorrect about ATG genes;

TLS Online TPP Program

#Question id: 860

#Unit 1. Structure and Function of Biomolecules

Select true ‘T’ AND false ‘F’ about ubiquitinylation

I. These ubiquitin-like modifiers control processes as diverse as nuclear import,

II. Regulated by the ubiquitin-like modifier Sumo, and autophagy,

III. Regulated by the ubiquitin-like modifier Atg8.

IV. For a protein to be efficiently degraded, it must be linked to a chain of at least four tandemly linked ubiquitin molecules in which Lys 34 of each ubiquitin forms an isopeptide bond with the C-terminal carboxyl group of the following ubiquitin.

TLS Online TPP Program

#Question id: 861

#Unit 1. Structure and Function of Biomolecules

Alexander Varshavsky discovered, the half-lives of many cytoplasmic proteins vary with the identities of their N-terminal residues via the so-called N-end rule:-

A. Destabilizing N-terminal residues Asp, Arg, Leu, Lys, and Phe have half-lives of

i. Only 2 to 3 minutes,

B. Stabilizing N-terminal residues Ala, Gly, Met, Ser, Thr, and Val have half-lives of

ii. >10 hours in prokaryotes

iii. >20 hours in eukaryotes.

TLS Online TPP Program

#Question id: 862

#Unit 1. Structure and Function of Biomolecules

Match the following

lysosomal protein degradation pathwaysFound in
1. Nonselectivea-well-nourished cells

i-containing the pentapeptide

Lys-Phe-Glu-Arg-Gln

2- Selectiveb-starving cells

TLS Online TPP Program

#Question id: 863

#Unit 1. Structure and Function of Biomolecules

Ubiquitinated proteins are proteolytically degraded in an ATP-dependent process mediated by a large (∼2500 kD, 26S) multiprotein complex named the 26S proteasome;