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TLS Online TPP Program

#Question id: 739

What is true about the rotation about bonds in a protein backbone?

#Unit 1. Molecules and their Interaction Relevant to Biology

  1. The rotation is free about all bonds in the backbone, except for the bond between the nitrogen and the alpha carbon in proline residues.

  2. The bond between the carbonyl carbon and nitrogen is restricted. Other bonds are free to rotate depending only on steric hindrance or the presence of proline residues.

  3. All bonds in the backbone have restricted rotation and partial double-bond character.

  4. The rotation is free only about the peptide bond. The other bonds are restricted by steric hindrance and the presence of proline residues.

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TLS Online TPP Program

#Question id: 19113

#Unit 8. Inheritance Biology

P, Q, and R are three different inbred, true-breeding strains of mice. A hybrid between P and Q is mated to R, and a hybrid between Q and R is mated to P. A male from the first mating is mated to a female from the second mating. What is the inbreeding coefficient of their progeny?
TLS Online TPP Program

#Question id: 19114

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
                                       
Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR42 in Family 1.
TLS Online TPP Program

#Question id: 19115

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
                
Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR43 in Family 1.
TLS Online TPP Program

#Question id: 19116

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
                             
Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR42 in Family 2.
TLS Online TPP Program

#Question id: 19117

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
 
Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR43 in Family 2.
TLS Online TPP Program

#Question id: 19118

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
                               
Calculate LOD scores for linkage at θ= 0.02 between SSR42 and SSR43 in Family 1.