Following statements are regarding to gangliosides.

A. They are ceramides with attached oligosaccharides that include at least one sialic acid residue.

B. They are ceramides with attached oligosaccharides that include at least one phasphatidic acid residue.

C. Sialic acid gives gangliosides the negative charge at pH 7 that distinguishes them from globosides.

D. Gangliosides are primarily components of cell-surface membranes and constitute a significant fraction (6%) of brain lipids.

Which of the following combination is correct?

TLS Online TPP Program

#Question id: 14764

#Unit 2. Cellular Organization

Match the following proteins (Column I) with their function (Column II). Which of the following is correct?

Column I	Column II
a. Profilin	i. binds to the (+) end of an actin filament, thereby inhibiting subunit addition or loss.
b. Cofilin	ii. blocks (−) ends, inhibits filament disassembly, to stabilize filaments
c. Thymosin-β4	iii. involved in actin treadmilling, but it binds specifically to F-actin in which the subunits contain ADP
d. Cap Z	iv. binds ADP–G-actin and catalyzes the exchange of ADP for ATP
e. Tropomodulin	v. binds to ATP–G-actin in such a way that it inhibits addition of the actin subunit to either end of the filament.

TLS Online TPP Program

#Question id: 14765

#Unit 2. Cellular Organization

Following statements are regarding to the formins which involve in filament assembly.

A. All formin family members have two adjacent domains in common, the so called FH1 and FH2 domains (formin-homology domains 1 and 2).

B. Two FH2 domains from two individual formin monomers associate to form a doughnut-shaped complex can form a dimer and nucleate filament assembly.

C. The FH1 domain of formin is rich in proline residues, which serve as sites for the binding of several profilin molecules.

D. The FH2 domain behaves as a landing site for profilin–ATP–G-actin to increase the local concentration of these complexes.

E. Formins are activated by membrane bound Rho-GTP, a Ras-related small GTPase.

Which of the following combination is correct?

TLS Online TPP Program

#Question id: 14766

#Unit 2. Cellular Organization

Which of the following statements does not belongs to the regulatory mechanism of the Arp2/3 complex by WASp and PI(4,5)P2?

TLS Online TPP Program

#Question id: 23798

#Unit 2. Cellular Organization

Myosin is

TLS Online TPP Program

#Question id: 23829

#Unit 2. Cellular Organization

Myosins don’t have 

TLS Online TPP Program

#Question id: 23830

#Unit 2. Cellular Organization

The first myosin isolated from skeletal muscle;