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TLS Online TPP Program
#Question id: 33985
#Unit 2. Cellular Organization
To analyze existing MARs that are bound to the matrix in vivo, what is correct order of method
A. Chromosomal loops decondensed by extracting the chromatin proteins.
B. Removal of the DNA loops by treatment with restriction nucleases
C. Amplification of MAR and sequencing
TLS Online TPP Program
#Question id: 33986
#Unit 2. Cellular Organization
What is the relationship between the chromosome scaffold of dividing cells and the matrix of interphase cells
A. The same DNA fragments that are found within the nuclear matrix in vivo can be retrieved from the metaphase scaffold
B. Fragments containing MAR sequences can bind to a metaphase scaffold; it is likely that DNA contains a single type of attachment site.
C. In interphase cells the attachment site is connected to the nuclear matrix, whereas in mitotic cells it is connected to the chromosome scaffold.
TLS Online TPP Program
#Question id: 34086
#Unit 3. Fundamental Processes
Replicators/replicons can be identified using a
TLS Online TPP Program
#Question id: 34087
#Unit 3. Fundamental Processes
A DNA containing which an origin of replication undergoing to initiation of replication and further, is digested with restriction endonuclease. Which shape of DNA segment can be found after digestion followed electrophoresis.
A. Y Shape B. Bubble shape C. bubble-to-Y-arc D. Circular
TLS Online TPP Program
#Question id: 34088
#Unit 3. Fundamental Processes
How can the 2D gels identify the DNA intermediates associated with a replication origin? Choose combination of correct statements
A. Y-shaped molecule that has three equal length arms will migrate the most slowly of all such molecules derived from a particular DNA fragment
B. A Y-shaped molecule with two very short replicated arms and a large replicated region will migrate very similarly to the unreplicated version of the same DNA fragment.
C. Y-shaped molecule that results from the almost completely replicated fragment is similar in shape to a linear molecule two times the size of the unreplicated fragment.
TLS Online TPP Program
#Question id: 34089
#Unit 3. Fundamental Processes
A. Replication Initiation require full methylation of the Dam target sites in the origin
B. Replication Initiation inhibited by hemimethylation of Dam target sites
C. Replication Initiation inhibited by nonmethylation of Dam target sites
D. An origin of nonmethylated DNA can function effectively
Choose true and false