TLS Online TPP Program

#Question id: 794


A single-stranded DNA molecule contains 40 nucleotides with equal amounts of A, C, G, and T. This DNA strand can combine with a complementary DNA strand to form a double-stranded DNA molecule. Which structural feature is found in the single-stranded DNA molecule?

#Unit 1. Molecules and their Interaction Relevant to Biology
  1. It can have a negatively-charged backbone composed of nitrogenous bases.

  2. Each 3’,5’-phosphodiester bond will contain one phosphate group linking two deoxyribose sugars.

  3. It can have one end with a 5’-phosphate group while the other end has a 2’-hydroxyl group.

  4. Each purine and pyrimidine will be paired with a complementary base.

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TLS Online TPP Program

#Question id: 19116

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
                             
Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR42 in Family 2.

TLS Online TPP Program

#Question id: 19117

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
 
Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR43 in Family 2.

TLS Online TPP Program

#Question id: 19118

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
                               
Calculate LOD scores for linkage at θ= 0.02 between SSR42 and SSR43 in Family 1.

TLS Online TPP Program

#Question id: 19119

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
                     
Calculate LOD scores for linkage at θ= 0.02 between SSR42 and SSR43 in Family 2.

TLS Online TPP Program

#Question id: 19120

#Unit 8. Inheritance Biology

Trisomy 18 is one of the most common trisomies observed in human populations. You prepare DNA samples from two unrelated infants, both with trisomy 18, and from their parents. You then type the infants and their parents for four SSRs distributed along chromosome 18:
 

                                      
In which parent did nondisjunction occur in Family 1?

TLS Online TPP Program

#Question id: 19121

#Unit 8. Inheritance Biology

Trisomy 18 is one of the most common trisomies observed in human populations. You prepare DNA samples from two unrelated infants, both with trisomy 18, and from their parents. You then type the infants and their parents for four SSRs distributed along chromosome 18:
 

                                              
In which parent did nondisjunction occur in Family 2?