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TLS Online TPP Program

#Question id: 878

Can a peptide bind more strongly to an unfolded than the same protein in a folded state?

#Unit 1. Molecules and their Interaction Relevant to Biology

  1. It will depend on the balance of favourable interactions (enthalpy) versus loss in conformational entropy. For the folded protein, the loss in conformational entropy is less upon binding.

  2. If the increased interactions for the unfolded protein can less than compensate the increased loss in conformational entropy then the net Gibbs free energy will be favourable.

  3. The unfolding do not cause the the appearance of hydrophobic sites of the surface of protein, so if the interaction of the peptide with the protein is depending on the hydrophobic site.

  4. If the binding site changed due to unfolding the binding will be stronger.

More Questions
TLS Online TPP Program

#Question id: 5162

#General Aptitude

Find 1/2 + 1/6 + 1/12 + 1/20 +------------------ +1/132=?
TLS Online TPP Program

#Question id: 26527

#Unit 3. Fundamental Processes

Which of the protein is essential for RNA pol I based transcription
TLS Online TPP Program

#Question id: 3625

#Unit 8. Inheritance Biology

If a heterozygous two recessive mutation at different site will give mutant phenotype when gene involved
TLS Online TPP Program

#Question id: 1230

#Unit 4. Cell Communication and Cell Signaling

Which of the following events occur(s) following the binding of a ligand to a G protein–coupled receptor that triggers release of Ca2+?

a. activation of protein kinase A by IP3

b. phospholipase cleavage of PIP2 to IP3 and DAG

c. release of DAG into the cytosol

d. IP3-mediated opening of Ca2+ channels in the ER membrane
TLS Online TPP Program

#Question id: 10959

#Unit 7. System Physiology – Animal

 Which of the following would best explain a prolonged bleeding time test?