TLS Online TPP Program

#Question id: 878


Can a peptide bind more strongly to an unfolded than the same protein in a folded state?

#Unit 1. Molecules and their Interaction Relevant to Biology
  1. It will depend on the balance of favourable interactions (enthalpy) versus loss in conformational entropy. For the folded protein, the loss in conformational entropy is less upon binding.

  2. If the increased interactions for the unfolded protein can less than compensate the increased loss in conformational entropy then the net Gibbs free energy will be favourable.

  3. The unfolding do not cause the the appearance of hydrophobic sites of the surface of protein, so if the interaction of the peptide with the protein is depending on the hydrophobic site.

  4. If the binding site changed due to unfolding the binding will be stronger.

More Questions
TLS Online TPP Program

#Question id: 33343

#Unit 2. Cellular Organization

Which of the following lipid carrier molecule is involved in the transport of peptidoglycan precursors across the cytoplasmic membrane to the growing point of the cell wall? 

TLS Online TPP Program

#Question id: 33344

#Unit 2. Cellular Organization

Which of the following enzyme insert cell wall precursors into the growing point of the cell wall and interacts with bactoprenol? 

TLS Online TPP Program

#Question id: 33345

#Unit 2. Cellular Organization

A culture was started by inoculating the medium with 100 cells having a generation time of 2 hours. Assuming the culture grows in ideal synchrony, what will be the number of cells in the culture at 8 hours?

TLS Online TPP Program

#Question id: 33346

#Unit 2. Cellular Organization

Growth of an organism was monitored at regular intervals of times and shown in the graph below. Around what time is the rate of growth zero?


TLS Online TPP Program

#Question id: 33347

#Unit 2. Cellular Organization

A rapidly growing bacterial species such as E. coli exhibits a typical phase of growth cycle in liquid nutrient broth (lag phase  log phase  stationary phase → death phase). If a bacterial culture has starting density of 103 cells/ml has a lag time of 10 minutes and a generation time of 10 minutes, what will the cell density be at (cells/ml) 50 minutes?

TLS Online TPP Program

#Question id: 3639

#Unit 3. Fundamental Processes

Replication of a bacterial chromosome normally starts at a fixed point called: