Correct approaches to protein structure prediction-:

i. Homology modeling	a) Methods is the Rosetta program, formulated by David Baker. To satisfy the program’s computational needs, a volunteer network of ∼100,000 computers, known as Rosetta@home, provides the 500,000 or so hours of processing time required to generate a structure.
ii. Structural genomics	b) which seeks to determine the X-ray structures of all representative domains, is aimed at expanding this predictive technique. The identification of structural homology is likely to provide clues as to a protein’s function even with imperfect structure prediction.
iii. Threading	c) Is a computational technique that attempts to determine the unknown structure of a protein by ascertaining whether it is consistent with a known protein structure. It does so by placing the unknown protein’s residues along the backbone of a known protein structure and then determining whether the amino acid side chains of the unknown protein are stable in that arrangement
iv. Ab initio	d) Aligns the sequence of interest with the sequence of a homologous protein or domain of known structure—compensating for amino acid substitutions, insertions, and deletions—through modeling and energy minimization calculations.

#Question id: 3283

#Unit 11. Evolution and Behavior

if the forward ( p in to q) and reverse ( q in to p) mutation rates for alleles at a locus are 1×10−1 and 1×10−2 per generation, respectively and the allelic frequencies are p = 0.20 and q = 0.80. if you assuming random matting population. Which of the following observation correct?

#Question id: 3284

#Unit 11. Evolution and Behavior

The fitness of three genotype are A1A1 < A1A2 = A2A2) Which of the following observation correct?

#Question id: 3285

#Unit 11. Evolution and Behavior

Natural selection continually operates on each species to keep up with improvements made by competing species; each species’ environment deteriorates as its competitors evolve new adaptations. This is known as

#Question id: 3286

#Unit 11. Evolution and Behavior

 In a human population, the gene frequencies of the alleles for the ABO system are as follows:

A = 29%                         B = 7%                                    0=64%

Assuming complete random mating and Hardy-Weinberg equilibrium,

What are the blood type A frequencies in this population?

#Question id: 3287

#Unit 11. Evolution and Behavior

Which statement is not an assumption of the Hardy–Weinberg law?

a. The allelic frequencies (p and q) are equal.

b. The population is randomly mating.

c. The population is large.

d. Locus is di-allelic

#Question id: 3288

#Unit 11. Evolution and Behavior

Migration causes changes in the allelic frequency of a population by introducing alleles from other populations. The magnitude of change due to migration depends on