Correct approaches to protein structure prediction-:

i. Homology modeling	a) Methods is the Rosetta program, formulated by David Baker. To satisfy the program’s computational needs, a volunteer network of ∼100,000 computers, known as Rosetta@home, provides the 500,000 or so hours of processing time required to generate a structure.
ii. Structural genomics	b) which seeks to determine the X-ray structures of all representative domains, is aimed at expanding this predictive technique. The identification of structural homology is likely to provide clues as to a protein’s function even with imperfect structure prediction.
iii. Threading	c) Is a computational technique that attempts to determine the unknown structure of a protein by ascertaining whether it is consistent with a known protein structure. It does so by placing the unknown protein’s residues along the backbone of a known protein structure and then determining whether the amino acid side chains of the unknown protein are stable in that arrangement
iv. Ab initio	d) Aligns the sequence of interest with the sequence of a homologous protein or domain of known structure—compensating for amino acid substitutions, insertions, and deletions—through modeling and energy minimization calculations.

#Question id: 3588

#Unit 8. Inheritance Biology

The ability to taste the chemical phenylthiocarbamide is an autosomal dominant phenotype, and the inability to taste it is recessive. If a taster woman with a nontaster father marries a taster man who in a previous marriage had a nontaster daughter. What is the probability that their first child will be tasters’ girl?

#Question id: 3589

#Unit 8. Inheritance Biology

Monohybrid Plant having genotype Tt were allowed to test cross , what is probability of random three plant selected that is

A- two tall, one dwarf      B- one tall, two dwarf       C- all tall

#Question id: 3590

#Unit 8. Inheritance Biology

Following parental cross and their expected progeny given in table

Which of the correct matching of parental cross with their expected progeny?

#Question id: 3591

#Unit 8. Inheritance Biology

Consider three yellow, round peas, labeled A, B, and C. Each was grown into a plant and crossed to a plant grown from a green, wrinkled pea. Exactly 100 peas issuing from each cross were sorted into phenotypic classes as follows

A:        51 yellow, round

            49 green, round

B:      100 yellow, round

C:  24 yellow, round

      26 yellow, wrinkled

      25 green, round

      25 green, wrinkled

What were the genotypes of A, B, and C respectively?

#Question id: 3592

#Unit 8. Inheritance Biology

In garden peas, tall (T) is dominant to short (t), Purple Flowers are (P) dominant to white flowers (p), Axial flowers (A) are dominant to terminal flowers (a), and yellow seeds (G) are dominant to green seeds (g). An individual from a true breeding line of tall, purple flowered, axial-flowered, yellow seeded pea plants is mated to an individual from a true breeding line of short, white flowered, terminal-flowered, green-seeded plants. The F1 are allowed to self-fertilize and produce an F2. What proportion of the F2 is expected to exhibit purple flowers and yellow seeds?

#Question id: 3593

#Unit 8. Inheritance Biology

In the cross Aa Bb Cc Dd X Aa Bb Cc Dd, in which all genes undergo independent assortment, what proportion of offspring are expected to be at least one heterozygous for locus gene?