When stress conditions arise, or when protein synthesis threatens to overwhelm the protein-folding capacity of the ER, unfolded proteins can accumulate. These conditions trigger the unfolded protein response (UPR)

a) unfolded protein response ensures to reduces the rate of protein synthesis by mTOR pathway

b) Amyloid aggregates that form before the UPR can come into play may be removed. Some are degraded by autophagy

c) Amyloid aggregates that can be removed by other mechanism such as lysosomal degradations

d)  UPR also bring the various systems into alignment by increasing the concentration of chaperones in the oxygen deprived conditions

Which of the following statements would be incorrect?

TLS Online TPP Program

#Question id: 28769

#Unit 2. Cellular Organization

Autophagy occurs in the following sequence of steps___

a) Nucleation of autophagosome formation by ATG9

b) Digestion of the inner membrane and the luminal contents of the autophagosome.

c) Fusion of the autophagosome with lysosomes, catalyzed by SNAREs.

d) Induction by inhibition of mTOR complex 1

e) Closure of the membrane cup to form autophagosome

TLS Online TPP Program

#Question id: 28770

#Unit 2. Cellular Organization

Autophagy can be either;

I- Nonselective autophagy

II- Selective autophagy

a) Closure of the membrane cup to form autophagosome

b) a bulk portion of cytoplasm is sequestered in autophagosomes

c) used to destroy invading microbes

d) Nucleation of autophagosome formation by ATG1

Find out the correct match statements of about selective as well as nonselective autophagy?

TLS Online TPP Program

#Question id: 28771

#Unit 2. Cellular Organization

Which of the following sorting signal that directs lysosomal hydrolases from the TGN to the late endosome?

TLS Online TPP Program

#Question id: 28772

#Unit 2. Cellular Organization

M6P residues are generated in the cis-Golgi by which of the following Golgi-resident enzymes?

a) N-acetylglucosamine (GlcNAc) phosphotransferase

b) ornithine transcarbamylase 

c) Phosphodiesterase

d) Catalases

TLS Online TPP Program

#Question id: 28773

#Unit 2. Cellular Organization

Which of the following coat protein complex specialized for endosome-to-TGN transport, also responsible for recycling the M6P receptor to the TGN?

TLS Online TPP Program

#Question id: 28774

#Unit 2. Cellular Organization

Mutation in a structural gene that codes for the lysosomal hydrolase that causes disease, which is?