When stress conditions arise, or when protein synthesis threatens to overwhelm the protein-folding capacity of the ER, unfolded proteins can accumulate. These conditions trigger the unfolded protein response (UPR)

a) unfolded protein response ensures to reduces the rate of protein synthesis by mTOR pathway

b) Amyloid aggregates that form before the UPR can come into play may be removed. Some are degraded by autophagy

c) Amyloid aggregates that can be removed by other mechanism such as lysosomal degradations

d)  UPR also bring the various systems into alignment by increasing the concentration of chaperones in the oxygen deprived conditions

Which of the following statements would be incorrect?

TLS Online TPP Program

#Question id: 4444

#Unit 3. Fundamental Processes

The homologous omega subunit of bacterial RNA polymerase in eukaryotic polymerases is,

TLS Online TPP Program

#Question id: 4445

#Unit 3. Fundamental Processes

The active site, which is made up of RPB1 and RPB2, from both these subunits, is found at the base of the pincers within a region called the “active center cleft” . The active site works according to the two-metal ion catalytic mechanism for nucleotide addition proposed for all types of polymerase;

TLS Online TPP Program

#Question id: 4446

#Unit 3. Fundamental Processes

Transcription start site is designated with the;

TLS Online TPP Program

#Question id: 4447

#Unit 3. Fundamental Processes

Sequences in the direction in which transcription proceeds are referred to as __?from the start site, and allotted a? value.

TLS Online TPP Program

#Question id: 4448

#Unit 3. Fundamental Processes

Three defined steps in a transcription cycle; choose correct one

1a. Closed complex	In this form, the DNA remains double-stranded, and the enzyme is bound to one face of the helix. I
1b. Open complex	In which the DNA strands separate over a distance of 13 bp around the start site to form the transcription bubble. In the next stage of initiation,
2. Promoter escape	Incorporation of the first 10 or so ribonucleotides is a rather inefficient process, and at that stage, the enzyme often releases short transcripts and then begins synthesis again
3. Initial transcribing complex.	Once an enzyme makes a transcript longer than 10 nucleotides, it is said to have

TLS Online TPP Program

#Question id: 4449

#Unit 3. Fundamental Processes

Promoters recognized by polymerase containing s70 share the following characteristic structure;