Following statements are regarding to regulation of S phase and mitotic cyclin levels in budding yeast.

A. In late anaphase, the anaphase-promoting complex (APC/C) ubiquitinylates S phase and mitotic cyclins.

B. In late anaphase, the anaphase-promoting complex (APC/C) phosphorylates S phase and mitotic cyclins.

C. During exit from mitosis and G1, Cdh1 is dephosphorylated and active; during S phase and mitosis, Cdh1 is phosphorylated and dissociates from APC/C, and APC/C becomes inactive.

D. During exit from mitosis and G1, Cdh1 is phosphorylated and active; during S phase and mitosis, Cdh1 is dephosphorylated and dissociates from APC/C, and APC/C becomes inactive.

E. The G1/S phase CDKs, which themselves are not APC/CCdh1 substrates, phosphorylate Cdh1 at the G1–S phase transition.

F. The G1/S phase CDKs, which themselves are not APC/CCdh1 substrates, ubiquitinylates Cdh1 at the G1–S phase transition.

Which of the following combination is correct?

TLS Online TPP Program

#Question id: 20277

#Unit 7. System Physiology – Animal

Which is structurally similar to growth hormone?

a. Prolactin

b. Lactogen

c. Dopamine 

d. Bromocriptine

Which of the above is/are correct? 

TLS Online TPP Program

#Question id: 20276

#Unit 7. System Physiology – Animal

Central diabetes insipidus is caused by failure of the posterior pituitary to secrete ADH and the following statements pertain to that disorder:

A. excretion of large volumes of dilute urine

B. the urine cannot be concentrated

C. produces large volumes of dilute urine

D. increased serum osmolarity

E. circulating levels of ADH are high

Which of the following is the correct combination of the statements given above?

TLS Online TPP Program

#Question id: 20275

#Unit 7. System Physiology – Animal

Vasopressin has two actions, one on the kidney and the other on vascular smooth muscle, Contraction of vascular smooth muscle are mediated by different receptors, different intracellular mechanisms, and different second messengers,

a. The receptor for ADH on vascular smooth muscle is a V1 receptor

b. The receptor for ADH on the vascular smooth muscle is a V2 receptor

c. The second messenger for this action is IP3/Ca2+ 

d. The second messenger is cAMP.

Which of the above is/are correct? 

TLS Online TPP Program

#Question id: 20274

#Unit 7. System Physiology – Animal

ADH has two actions, one on the kidney and the other on vascular smooth muscle, these actions are mediated by different receptors, different intracellular mechanisms, and different secondary messengers.

a. The major action of ADH is to increase the water permeability of principal cells in the late distal tubule and collecting duct.

b. The receptor for ADH on the principal cells is a V2 receptor, which is coupled to adenylyl cyclase via a Gs protein. 

c. The second messenger is cAMP, via phosphorylation steps, directs the insertion of water channels, aquaporin 2 (AQP2), in luminal membranes.

d. The receptor for ADH on the principal cells is a V1 receptor, which is coupled to phospholipase C via Gq protein.

Which one of the following combination of above statements is correct?

TLS Online TPP Program

#Question id: 20273

#Unit 7. System Physiology – Animal

Primary site of action of thiazide diuretics in the nephron is;

TLS Online TPP Program

#Question id: 20272

#Unit 7. System Physiology – Animal

The factors that stimulate or inhibit the secretion of ADH by the posterior pituitary are:

a. Pain, nausea, hypoglycemia, and various drugs all inhibit the secretion of ADH. 

b. Pain, nausea, hypoglycemia, and various drugs all stimulate the secretion of ADH. 

c. Ethanol, α-adrenergic agonists, and atrial natriuretic peptide inhibit secretion of ADH.

d. Nicotine, opiates, antineoplastic agents stimulate the secretion of ADH. 

Which one of the following combinations of above statements is correct?